Cell Biology Antibodies 4

Anti-LAMB3 Antibody (CAB13663)

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SKU:
CAB13663
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-LAMB3 Antibody
Antibody SKU:CAB13663
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 18-230 of human LAMB3 (NP_000219.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 18-230 of human LAMB3 (NP_000219.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QQAC SRGA CYPP VGDL LVGR TRFL RASS TCGL TKPE TYCT QYGE WQMK CCKC DSRQ PHNY YSHR VENV ASSS GPMR WWQS QNDV NPVS LQLD LDRR FQLQ EVMM EFQG PMPA GMLI ERSS DFGK TWRV YQYL AADC TSTF PRVR QGRP QSWQ DVRC QSLP QRPN ARLN GGKV QLNL MDLV SGIP ATQS QKIQ EVGE ITNL RVNF TRLA PVPQ R
Gene ID:3914
Uniprot:Q13751
Cellular Location:Secreted, basement membrane, extracellular matrix, extracellular space
Calculated MW:129kDa
Observed MW:131kDa
Synonyms:LAMB3, AI1A, BM600-125KDA, LAM5, LAMNB1
Background:The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene.
UniProt Protein Function:LAMB3: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMB3 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB); also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. Defects in LAMB3 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). GABEB is a non- lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: laminin-5 complex; extracellular region

Molecular Function:protein binding; protein complex binding; structural molecule activity

Biological Process: extracellular matrix disassembly; hemidesmosome assembly; extracellular matrix organization and biogenesis; epidermis development; brown fat cell differentiation; cell adhesion

Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type; Epidermolysis Bullosa, Junctional, Herlitz Type; Amelogenesis Imperfecta, Type Ia

NCBI Summary:The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q13751
NCBI GenInfo Identifier:62868215
NCBI Gene ID:3914
NCBI Accession:NP_000219.2
UniProt Secondary Accession:Q13751,O14947, Q14733, Q9UJK4, Q9UJL1, D3DT88,
UniProt Related Accession:Q13751
Molecular Weight:129,572 Da
NCBI Full Name:laminin subunit beta-3
NCBI Synonym Full Names:laminin, beta 3
NCBI Official Symbol:LAMB3  
NCBI Official Synonym Symbols:LAM5; LAMNB1; BM600-125KDA  
NCBI Protein Information:laminin subunit beta-3; nicein-125kDa; kalinin-140kDa; kalinin B1 chain; laminin B1k chain; laminin S B3 chain; nicein subunit beta; kalinin subunit beta; epiligrin subunit bata; laminin-5 subunit beta; laminin, beta 3 (nicein (125kD), kalinin (140kD), BM600 (125kD))
UniProt Protein Name:Laminin subunit beta-3
UniProt Synonym Protein Names:Epiligrin subunit bata; Kalinin B1 chain; Kalinin subunit beta; Laminin B1k chain; Laminin-5 subunit beta; Nicein subunit beta
Protein Family:Laminin
UniProt Gene Name:LAMB3  
UniProt Entry Name:LAMB3_HUMAN
Anti-LAMB3 Antibody (CAB13663)Western blot analysis of extracts of rat liver, using LAMB3 Antibody (CAB13663) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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