Metabolism Antibodies 1
Anti-LALBA Antibody (CAB12690)
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- SKU:
- CAB12690
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-LALBA Antibody |
| Antibody SKU: | CAB12690 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-142 of human LALBA (NP_002280.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | MCF7, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-142 of human LALBA (NP_002280.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KQFT KCEL SQLL KDID GYGG IALP ELIC TMFH TSGY DTQA IVEN NEST EYGL FQIS NKLW CKSS QVPQ SRNI CDIS CDKF LDDD ITDD IMCA KKIL DIKG IDYW LAHK ALCT EKLE QWLC EKL |
| Gene ID: | 3906 |
| Uniprot: | P00709 |
| Cellular Location: | Secreted |
| Calculated MW: | 16kDa |
| Observed MW: | 14-16kDa |
| Synonyms: | LALBA, LYZG |
| Background: | This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1, 4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. |
| UniProt Protein Function: | LALBA: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. Belongs to the glycosyl hydrolase 22 family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Transferase; Apoptosis Chromosomal Location of Human Ortholog: 12q13 Cellular Component: extracellular space; Golgi lumen; Golgi membrane Biological Process: apoptosis; cell-cell signaling; defense response to bacterium; lactose biosynthetic process; signal transduction |
| NCBI Summary: | This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P00709 |
| NCBI GenInfo Identifier: | 126001 |
| NCBI Gene ID: | 3906 |
| NCBI Accession: | P00709.1 |
| UniProt Secondary Accession: | P00709,Q6FGX0, Q9UDK4, |
| UniProt Related Accession: | P00709 |
| Molecular Weight: | 16,225 Da |
| NCBI Full Name: | Alpha-lactalbumin |
| NCBI Synonym Full Names: | lactalbumin alpha |
| NCBI Official Symbol: | LALBA |
| NCBI Official Synonym Symbols: | LYZG |
| NCBI Protein Information: | alpha-lactalbumin |
| UniProt Protein Name: | Alpha-lactalbumin |
| UniProt Synonym Protein Names: | Lactose synthase B protein; Lysozyme-like protein 7 |
| Protein Family: | Alpha-lactalbumin |
| UniProt Gene Name: | LALBA |
| UniProt Entry Name: | LALBA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LALBA antibody (CAB12690) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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