Immunology Antibodies 1
Anti-LAIR2 Antibody (CAB14376)
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- SKU:
- CAB14376
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-LAIR2 Antibody |
| Antibody SKU: | CAB14376 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-120 of human LAIR2 (NP_002279.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, Mouse kidney, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-120 of human LAIR2 (NP_002279.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QEGA LPRP SISA EPGT VISP GSHV TFMC RGPV GVQT FRLE REDR AKYK DSYN VFRL GPSE SEAR FHID SVSE GNAG LYRC LYYK PPGW SEHS DFLE LLV |
| Gene ID: | 3904 |
| Uniprot: | Q6ISS4 |
| Cellular Location: | Secreted |
| Calculated MW: | 14kDa/16kDa |
| Observed MW: | 16kDa |
| Synonyms: | LAIR2, CD306 |
| Background: | The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. |
| UniProt Protein Function: | LAIR-2: 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: extracellular region |
| NCBI Summary: | The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| UniProt Code: | Q6ISS4 |
| NCBI GenInfo Identifier: | 10947101 |
| NCBI Gene ID: | 3904 |
| NCBI Accession: | NP_002279.2 |
| UniProt Secondary Accession: | Q6ISS4,Q6PEZ4, |
| UniProt Related Accession: | Q6ISS4 |
| Molecular Weight: | |
| NCBI Full Name: | leukocyte-associated immunoglobulin-like receptor 2 isoform a |
| NCBI Synonym Full Names: | leukocyte-associated immunoglobulin-like receptor 2 |
| NCBI Official Symbol: | LAIR2 |
| NCBI Official Synonym Symbols: | CD306; MGC71634 |
| NCBI Protein Information: | leukocyte-associated immunoglobulin-like receptor 2; LAIR-2; OTTHUMP00000068389; OTTHUMP00000068390; leukocyte-associated Ig-like receptor 2; leukocyte-associated Ig-like receptor-2 |
| UniProt Protein Name: | Leukocyte-associated immunoglobulin-like receptor 2 |
| Protein Family: | Leukocyte-associated immunoglobulin-like receptor |
| UniProt Gene Name: | |
| UniProt Entry Name: | LAIR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LAIR2 antibody (CAB14376) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunofluorescence analysis of human placenta using LAIR2 antibody (CAB14376) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse placenta using LAIR2 antibody (CAB14376) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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