Immunology Antibodies 2
Anti-LAG3 Antibody (CAB2996)
- SKU:
- CAB2996
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-LAG3 Antibody |
| Antibody SKU: | CAB2996 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-170 of human LAG3 (NP_002277.4). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:4000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, Raji, HepG2, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-170 of human LAG3 (NP_002277.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VPVV WAQE GAPA QLPC SPTI PLQD LSLL RRAG VTWQ HQPD SGPP AAAP GHPL APGP HPAA PSSW GPRP RRYT VLSV GPGG LRSG RLPL QPRV QLDE RGRQ RGDF SLWL RPAR RADA GEYR AAVH LRDR ALSC RLRL RLGQ AS |
| Gene ID: | 3902 |
| Uniprot: | P18627 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 39kDa/57kDa |
| Observed MW: | 72kDa |
| Synonyms: | LAG3, CD223 |
| Background: | Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. |
| UniProt Protein Function: | LAG3: Involved in lymphocyte activation. Binds to HLA class-II antigens. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13.32 Cellular Component: integral to membrane; external side of plasma membrane Molecular Function:transmembrane receptor activity; antigen binding; MHC class II protein binding Biological Process: cell surface receptor linked signal transduction; negative regulation of interleukin-2 biosynthetic process; positive regulation of natural killer cell mediated cytotoxicity; negative regulation of T cell activation |
| NCBI Summary: | Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P18627 |
| NCBI GenInfo Identifier: | 251757512 |
| NCBI Gene ID: | 3902 |
| NCBI Accession: | P18627.5 |
| UniProt Related Accession: | P18627 |
| Molecular Weight: | |
| NCBI Full Name: | Lymphocyte activation gene 3 protein |
| NCBI Synonym Full Names: | lymphocyte activating 3 |
| NCBI Official Symbol: | LAG3 |
| NCBI Official Synonym Symbols: | CD223 |
| NCBI Protein Information: | lymphocyte activation gene 3 protein |
| UniProt Protein Name: | Lymphocyte activation gene 3 protein |
| UniProt Synonym Protein Names: | Protein FDC; CD_antigen: CD223 |
| Protein Family: | Lymphocyte activation gene 3 protein |
| UniProt Gene Name: | LAG3 |
| UniProt Entry Name: | LAG3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LAG3 antibody (CAB2996) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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