Signal Transduction Antibodies 3

Anti-Lactoperoxidase Antibody (CAB8053)

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SKU:
CAB8053
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:LPO Rabbit Polyclonal Antibody
Antibody SKU:CAB8053
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-280 of human LPO (NP_006142.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:BT-474, MCF7
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-280 of human LPO (NP_006142.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QTTR TSAI SDTV SQAK VQVN KAFL DSRT RLKT AMSS ETPT SRQL SEYL KHAK GRTR TAIR NGQV WEES LKRL RQKA SLTN VTDP SLDL TSLS LEVG CGAP APVV RCDP CSPY RTIT GDCN NRRK PALG AANR ALAR WLPA EYED GLSL PFGW TPGK TRNG FPLP LARE VSNK IVGY LNEE GVLD QNRS LLFM QWGQ IVDH DLDF APDT ELGS SEYS KAQC DEYC IQGD NCFP IMFP PNDP KAGT QGKC MPFF RA
Gene ID:4025
Uniprot:P22079
Cellular Location:Secreted
Calculated MW:70kDa/80kDa
Observed MW:70kDa
Synonyms:LPO, SPO
Background:This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
UniProt Protein Function:LPO: May contribute to airway host defense against infection. Belongs to the peroxidase family. XPO subfamily.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Oxidoreductase; EC 1.11.1.7; Secreted

Chromosomal Location of Human Ortholog: 17q23.1

Cellular Component: extracellular space; basolateral plasma membrane; cytoplasm

Molecular Function:metal ion binding; heme binding

Biological Process: hydrogen peroxide catabolic process; defense response to bacterium; thiocyanate metabolic process; response to oxidative stress; detection of chemical stimulus involved in sensory perception of bitter taste

NCBI Summary:This gene encodes an oxidoreductase secreted from salivary, mammary, and other mucosal glands that functions as a natural antibacterial agent. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Code:P22079
NCBI GenInfo Identifier:12643419
NCBI Gene ID:4025
NCBI Accession:P22079.2
UniProt Secondary Accession:P22079,Q13408, Q3KNQ2, A5JUY4, E7EMJ3,
UniProt Related Accession:P22079
Molecular Weight:70,984 Da
NCBI Full Name:Lactoperoxidase
NCBI Synonym Full Names:lactoperoxidase
NCBI Official Symbol:LPO  
NCBI Official Synonym Symbols:SPO  
NCBI Protein Information:lactoperoxidase; salivary peroxidase
UniProt Protein Name:Lactoperoxidase
UniProt Synonym Protein Names:Salivary peroxidase; SPO
Protein Family:Lactoperoxidase
UniProt Gene Name:LPO  
UniProt Entry Name:PERL_HUMAN
Anti-Lactoperoxidase Polyclonal Antibody (CAB8053)Western blot analysis of extracts of various cell lines, using LPO antibody (CAB8053) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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