Cell Biology Antibodies 15
Anti-LACTB Antibody (CAB7144)
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- SKU:
- CAB7144
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LACTB Antibody |
| Antibody SKU: | CAB7144 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 298-547 of human LACTB (NP_116246.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SKOV3, Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 298-547 of human LACTB (NP_116246.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FENS IESL RLFK NDPL FFKP GSQF LYST FGYT LLAA IVER ASGC KYLD YMQK IFHD LDML TTVQ EENE PVIY NRAR FYVY NKKK RLVN TPYV DNSY KWAG GGFL STVG DLLK FGNA MLYG YQVG LFKN SNEN LLPG YLKP ETMV MMWT PVPN TEMS WDKE GKYA MAWG VVER KQTY GSCR KQRH YASH TGGA VGAS SVLL VLPE ELDT ETIN NKVP PRGI IVSI ICNM QSVG LNST ALKI ALEF DKDR SD |
| Gene ID: | 114294 |
| Uniprot: | P83111 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 41kDa/60kDa |
| Observed MW: | 55kDa |
| Synonyms: | LACTB, G24, MRPL56 |
| Background: | This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. |
| UniProt Protein Function: | Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (PubMed:28329758). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (PubMed:28329758). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758). |
| NCBI Summary: | This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Dec 2013] |
| UniProt Code: | P83111 |
| NCBI GenInfo Identifier: | 568384811 |
| NCBI Gene ID: | 114294 |
| NCBI Accession: | NP_001275514.1 |
| UniProt Secondary Accession: | P83111,P83096, |
| UniProt Related Accession: | P83111 |
| Molecular Weight: | Predicted MW: 61kDa |
| NCBI Full Name: | serine beta-lactamase-like protein LACTB, mitochondrial isoform c |
| NCBI Synonym Full Names: | lactamase beta |
| NCBI Official Symbol: | LACTB |
| NCBI Official Synonym Symbols: | G24; MRPL56 |
| NCBI Protein Information: | serine beta-lactamase-like protein LACTB, mitochondrial |
| UniProt Protein Name: | Serine beta-lactamase-like protein LACTB, mitochondrial |
| Protein Family: | Serine beta-lactamase-like protein |
| UniProt Gene Name: | LACTB |
 | Western blot - LACTB Rabbit pAb (CAB7144) |
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