Cell Biology Antibodies 5

Anti-LACRT Antibody (CAB14632)

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SKU:
CAB14632
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-LACRT Antibody
Antibody SKU:CAB14632
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LACRT (NP_150593.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse heart, Mouse thymus
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LACRT (NP_150593.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKFT TLLF LAAV AGAL VYAE DASS DSTG ADPA QEAG TSKP NEEI SGPA EPAS PPET TTTA QETS AAAV QGTA KVTS SRQE LNPL KSIV EKSI LLTE QALA
Gene ID:90070
Uniprot:Q9GZZ8
Cellular Location:Secreted
Calculated MW:14kDa
Observed MW:14kDa
Synonyms:LACRT, lacritin
Background:The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium.
UniProt Protein Function:LACRT: Modulates secretion by lacrimal acinar cells.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: extracellular region; extracellular space; secretory granule

Molecular Function:collagen binding; fibronectin binding; growth factor activity; laminin-1 binding; protein N-terminus binding

Biological Process: calcineurin-NFAT signaling pathway; calcium-mediated signaling; defense response to bacterium; negative regulation of apoptosis; negative regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of calcium-mediated signaling; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of macroautophagy; positive regulation of NFAT protein import into nucleus; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of secretion; protein amino acid acetylation; protein localization to Golgi apparatus

NCBI Summary:The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]
UniProt Code:Q9GZZ8
NCBI GenInfo Identifier:15187164
NCBI Gene ID:90070
NCBI Accession:NP_150593.1
UniProt Related Accession:Q9GZZ8
Molecular Weight:
NCBI Full Name:extracellular glycoprotein lacritin
NCBI Synonym Full Names:lacritin
NCBI Official Symbol:LACRT  
NCBI Protein Information:extracellular glycoprotein lacritin
UniProt Protein Name:Extracellular glycoprotein lacritin
Protein Family:Extracellular glycoprotein lacritin
UniProt Gene Name:LACRT  
Anti-LACRT Antibody (CAB14632)Western blot analysis of extracts of various cell lines, using LACRT antibody (CAB14632) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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