Epigenetics & Nuclear Signaling Antibodies 1

Anti-L3MBTL2 Antibody (CAB10331)

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SKU:
CAB10331
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-L3MBTL2 Antibody
Antibody SKU:CAB10331
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 486-705 of human L3MBTL2 (NP_113676.2).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:HeLa, HL-60, HT-29
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 486-705 of human L3MBTL2 (NP_113676.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PATF CQKN DIEL TPPK GYEA QTFN WENY LEKT KSKA APSR LFNM DCPN HGFK VGMK LEAV DLME PRLI CVAT VKRV VHRL LSIH FDGW DSEY DQWV DCES PDIY PVGW CELT GYQL QPPV AAEP ATPL KAKE ATKK KKKQ FGKK RKRI PPTK TRPL RQGS KKPL LEDD PQGA RKIS SEPV PGEI IAVR VKEE HLDV ASPD KASS PELP VSVE NIKQ ETDD
Gene ID:83746
Uniprot:Q969R5
Cellular Location:Nucleus
Calculated MW:69kDa/79kDa
Observed MW:95kDa
Synonyms:L3MBTL2, H-l(3)mbt-l, L3MBT
Background:
UniProt Protein Function:L3MBTL2: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Histone-binding

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: nucleoplasm; nucleus

Molecular Function:histone binding; methylated histone residue binding; protein binding

Biological Process: protein sumoylation

UniProt Code:Q969R5
NCBI GenInfo Identifier:27734418
NCBI Gene ID:83746
NCBI Accession:Q969R5.1
UniProt Secondary Accession:Q969R5,Q8TEN1, Q96SC4, Q9BQI2, Q9UGS4,
UniProt Related Accession:Q969R5
Molecular Weight:79kDa
NCBI Full Name:Lethal(3)malignant brain tumor-like protein 2
NCBI Synonym Full Names:L3MBTL2 polycomb repressive complex 1 subunit
NCBI Official Symbol:L3MBTL2  
NCBI Official Synonym Symbols:L3MBT; H-l(3)mbt-l  
NCBI Protein Information:lethal(3)malignant brain tumor-like protein 2
UniProt Protein Name:Lethal(3)malignant brain tumor-like protein 2
Protein Family:Lethal(3)malignant brain tumor-like protein
UniProt Gene Name:L3MBTL2  
Anti-L3MBTL2 Antibody (CAB10331)Western blot analysis of extracts of various cell lines, using L3MBTL2 antibody (CAB10331) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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