Epigenetics & Nuclear Signaling Antibodies 4
Anti-L3MBTL1 Antibody (CAB7090)
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- SKU:
- CAB7090
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-L3MBTL1 Antibody |
| Antibody SKU: | CAB7090 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 533-772 of human L3MBTL1 (NP_056293.4). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 533-772 of human L3MBTL1 (NP_056293.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PLSY RSLP HTRT SKYS FHHR KCPT PGCD GSGH VTGK FTAH HCLS GCPL AERN QSRL KAEL SDSE ASAR KKNL SGFS PRKK PRHH GRIG RPPK YRKI PQED FQTL TPDV VHQS LFMS ALSA HPDR SLSV CWEQ HCKL LPGV AGIS ASTV AKWT IDEV FGFV QTLT GCED QARL FKDE ARIV RVTH VSGK TLVW TVAQ LGDL VCSD HLQE GKGI LETG VHSL LCSL PTHL LAKL SFAS DSQY |
| Gene ID: | 26013 |
| Uniprot: | Q9Y468 |
| Cellular Location: | Nucleus |
| Calculated MW: | 43kDa/82kDa/83kDa/85kDa/92kDa |
| Observed MW: |
| Synonyms: | L3MBTL1, H-L(3)MBT, L3MBTL, ZC2HC3, dJ138B7.3 |
| Background: | This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. |
| NCBI Summary: | This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010] |
| UniProt Code: | Q9Y468 |
| NCBI GenInfo Identifier: | 325511398 |
| NCBI Gene ID: | 26013 |
| NCBI Accession: | Q9Y468.3 |
| UniProt Secondary Accession: | Q9Y468,Q5H8Y8, Q5H8Y9, Q8IUV7, Q9H1E6, Q9H1G5, Q9UG06 Q9UJB9, Q9Y4C9, B4DRC9, E1P5W7, |
| UniProt Related Accession: | Q9Y468 |
| Molecular Weight: | 92,297 Da |
| NCBI Full Name: | Lethal(3)malignant brain tumor-like protein 1 |
| NCBI Synonym Full Names: | l(3)mbt-like 1 (Drosophila) |
| NCBI Official Symbol: | L3MBTL1 |
| NCBI Official Synonym Symbols: | L3MBTL; ZC2HC3; H-L(3)MBT; dJ138B7.3 |
| NCBI Protein Information: | lethal(3)malignant brain tumor-like protein 1 |
| UniProt Protein Name: | Lethal(3)malignant brain tumor-like protein 1 |
| UniProt Synonym Protein Names: | L(3)mbt protein homolog; L3MBTL1 |
| Protein Family: | Lethal(3)malignant brain tumor-like protein |
| UniProt Gene Name: | L3MBTL1 |
| UniProt Entry Name: | LMBL1_HUMAN |
 | Immunofluorescence analysis of A549 cells using L3MBTL1 antibody (CAB7090). |
 | Immunofluorescence analysis of GFP-RNF168 transgenic U2OS cells using L3MBTL1 antibody (CAB7090).Green:GFP-RNF168 fusion protein expression for DNA damage marker. Blue:DAPI for nuclear staining.RNF168(GFP) can be used to mark cells damaged by UV-A laser for they always gather around DNA damage region. |
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