Anti-L-Plastin/LCP1 Antibody (CAB4664)
- SKU:
- CAB4664
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CP64
- Synonyms:
- HEL-S-37
- Synonyms:
- L-PLASTIN
- Synonyms:
- LC64P
- Synonyms:
- LPL
- Synonyms:
- PLS2
- Research Area:
- Cell Biology
Description
| Product Name: | L-Plastin/LCP1 Rabbit mAb |
| Product Code: | CAB4664 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2 |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human L-Plastin/LCP1 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | Raji |
| Immunogen: | A synthesized peptide derived from human L-Plastin/LCP1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3936 |
| Uniprot: | P13796 |
| Calculated MW: | 70kDa |
| Observed MW: | 70KDa |
| UniProt Protein Function: | L-plastin: Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Monomer. Interacts with AIF1. Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T- lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 13q14.3 Cellular Component: actin cytoskeleton; actin filament; actin filament bundle; cytoplasm; cytosol; extracellular space; filopodium; focal adhesion; plasma membrane; podosome; ruffle; stress fiber Molecular Function:actin filament binding; GTPase binding Biological Process: actin filament bundle formation; cell migration; extracellular matrix disassembly; regulation of intracellular protein transport; T cell activation during immune response |
| NCBI Summary: | Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13796 |
| NCBI GenInfo Identifier: | 308153685 |
| NCBI Gene ID: | 3936 |
| NCBI Accession: | P13796.6 |
| UniProt Secondary Accession: | P13796,Q5TBN4, B2R613, B4DUA0, |
| UniProt Related Accession: | P13796 |
| Molecular Weight: | 21,792 Da |
| NCBI Full Name: | Plastin-2 |
| NCBI Synonym Full Names: | lymphocyte cytosolic protein 1 |
| NCBI Official Symbol: | LCP1 |
| NCBI Official Synonym Symbols: | LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN |
| NCBI Protein Information: | plastin-2 |
| UniProt Protein Name: | Plastin-2 |
| UniProt Synonym Protein Names: | L-plastin; LC64P; Lymphocyte cytosolic protein 1; LCP-1 |
| Protein Family: | Larval cuticle protein |
| UniProt Gene Name: | LCP1 |
| UniProt Entry Name: | PLSL_HUMAN |
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