Cell Biology Antibodies 7
Anti-KSR2 Antibody (CAB17866)
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- SKU:
- CAB17866
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-KSR2 Antibody |
| Antibody SKU: | CAB17866 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 780-890 of human KSR2 (NP_775869.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 780-890 of human KSR2 (NP_775869.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ISGV LQAG RRED KLRI QNGW LCHL APEI IRQL SPDT EEDK LPFS KHSD VFAL GTIW YELH AREW PFKT QPAE AIIW QMGT GMKP NLSQ IGMG KEIS DILL FCWA FEQE ERP |
| Gene ID: | 283455 |
| Uniprot: | Q6VAB6 |
| Cellular Location: | |
| Calculated MW: | 108kDa |
| Observed MW: | Refer to figures |
| Synonyms: | KSR2 |
| Background: |
| UniProt Protein Function: | KSR2: Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, TKL; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); TKL group; RAF family Chromosomal Location of Human Ortholog: 12q24.22-q24.23 Cellular Component: cytoplasm; membrane Molecular Function:ATP binding; metal ion binding; protein serine/threonine kinase activity Biological Process: protein amino acid phosphorylation |
| UniProt Code: | Q6VAB6 |
| NCBI GenInfo Identifier: | 148886599 |
| NCBI Gene ID: | 283455 |
| NCBI Accession: | Q6VAB6.2 |
| UniProt Secondary Accession: | Q6VAB6,Q3B828, Q8N775, A0PJT2, |
| UniProt Related Accession: | Q6VAB6 |
| Molecular Weight: | 49,607 Da |
| NCBI Full Name: | Kinase suppressor of Ras 2 |
| NCBI Synonym Full Names: | kinase suppressor of ras 2 |
| NCBI Official Symbol: | KSR2 |
| NCBI Protein Information: | kinase suppressor of Ras 2 |
| UniProt Protein Name: | Kinase suppressor of Ras 2 |
| Protein Family: | Kinase suppressor of Ras |
| UniProt Gene Name: | KSR2 |
| UniProt Entry Name: | KSR2_HUMAN |
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