Description
Antibody Name: | Anti-KRT80 Antibody (CAB5165) |
Antibody SKU: | CAB5165 |
Antibody Size: | 100µL |
Application: | Western blotting, Immunofluorescence |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 242-452 of human KRT80 (NP_872313.2). |
Application: | Western blotting, Immunofluorescence |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 242-452 of human KRT80 (NP_872313.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | SRCH IDLS GIVE EVKA QYDA VAAR SLEE AEAY SRSQ LEEQ AARS AEYG SSLQ SSRS EIAD LNVR IQKL RSQI LSVK SHCL KLEE NIKT AEEQ GELA FQDA KTKL AQLE AALQ QAKQ DMAR QLRK YQEL MNVK LALD IEIA TYRK LVEG EEGR MDSP SATV VSAV QSRC KTAA SRSG LSKA PSRK KKGS KGPV IKIT EMSE KYFS QESE VSE |
Cellular Location: | |
Calculated MW: | 47kDa/50kDa/54kDa |
Observed MW: | Refer to figures |
Synonyms: | KRT80, KB20 |
Background: | Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene. |
Immunofluorescence analysis of mouse skin using KRT80 Rabbit pAb at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining. | |
Immunofluorescence analysis of A431 cells using KRT80 Rabbit pAb at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining. | |
Immunofluorescence analysis of rat skin using KRT80 Rabbit pAb at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining. |