Anti-KRT5/KRT6A Antibody (MACO0502)
- SKU:
- MACO0502
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1, Kappa
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Monoclonal Antibody
- Conjugation:
- Unconjugated
Description
| Product Name: | Anti-KRT5/KRT6A Antibody |
| Product Sku: | MACO0502 |
| Size: | 50ul |
| Host Species: | Mouse |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from human Cytokeratin 5/6 |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Clonality: | Monoclonal |
| Isotype: | IgG1, Kappa |
| Conjugate: | Non-conjugated |
| Background: | cytoplasm, cytosol, extracellular exosome, intermediate filament, keratin filament, membrane, nucleus, scaffold protein binding, structural constituent of cytoskeleton, cornification |
| Synonyms: | Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5), KRT5 |
 | IHC image of MACO0502 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse IgG polymer labeled by HRP and visualized using 0.05% DAB. |
 | IHC image of MACO0502 diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| UniProt Protein Function: | K5: Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP. Belongs to the intermediate filament family. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: mitochondrion; membrane; cytoplasm; keratin filament; plasma membrane; intermediate filament; cytosol; nucleus Molecular Function:protein binding; structural constituent of cytoskeleton Biological Process: epidermis development; hemidesmosome assembly Disease: Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Simplex, Generalized; Dowling-degos Disease 1; Epidermolysis Bullosa Simplex With Migratory Circinate Erythema; Epidermolysis Bullosa Simplex, Autosomal Recessive 1; Epidermolysis Bullosa Simplex With Mottled Pigmentation; Epidermolysis Bullosa Simplex, Dowling-meara Type |
| NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13647 |
| NCBI GenInfo Identifier: | 143811411 |
| NCBI Gene ID: | 3852 |
| NCBI Accession: | P13647.3 |
| UniProt Secondary Accession: | P13647,Q6PI71, Q6UBJ0, Q8TA91, |
| UniProt Related Accession: | P13647 |
| Molecular Weight: | 590 |
| NCBI Full Name: | Keratin, type II cytoskeletal 5 |
| NCBI Synonym Full Names: | keratin 5 |
| NCBI Official Symbol: | KRT5 |
| NCBI Official Synonym Symbols: | K5; CK5; DDD; DDD1; EBS2; KRT5A |
| NCBI Protein Information: | keratin, type II cytoskeletal 5; CK-5; cytokeratin-5; 58 kda cytokeratin; type-II keratin Kb5; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) |
| UniProt Protein Name: | Keratin, type II cytoskeletal 5 |
| UniProt Synonym Protein Names: | 58 kDa cytokeratin; Cytokeratin-5; CK-5; Keratin-5; K5; Type-II keratin Kb5 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT5 |
| UniProt Entry Name: | K2C5_HUMAN |
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