Cell Biology Antibodies 1
Anti-KRT17 Antibody (CAB0123)
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- SKU:
- CAB0123
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-KRT17 Antibody |
| Antibody SKU: | CAB0123 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 133-432 of human KRT17 (NP_000413.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | HeLa, HepG2, OVCAR3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 133-432 of human KRT17 (NP_000413.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QYYR TIEE LQNK ILTA TVDN ANIL LQID NARL AADD FRTK FETE QALR LSVE ADIN GLRR VLDE LTLA RADL EMQI ENLK EELA YLKK NHEE EMNA LRGQ VGGE INVE MDAA PGVD LSRI LNEM RDQY EKMA EKNR KDAE DWFF SKTE ELNR EVAT NSEL VQSG KSEI SELR RTMQ ALEI ELQS QLSM KASL EGNL AETE NRYC VQLS QIQG LIGS VEEQ LAQL RCEM EQQN QEYK ILLD VKTR LEQE IATY RRLL EGED AHLT QYKK EPVT TRQV RTIV EEVQ DGKV ISSR EQVH QTTR |
| Gene ID: | 3872 |
| Uniprot: | Q04695 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 48kDa |
| Observed MW: | 48kDa |
| Synonyms: | KRT17, 39.1, CK-17, K17, PC, PC2, PCHC1 |
| Background: | This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. |
| UniProt Protein Function: | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. |
| NCBI Summary: | This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008] |
| UniProt Code: | Q04695 |
| NCBI GenInfo Identifier: | 547751 |
| NCBI Gene ID: | 3872 |
| NCBI Accession: | Q04695.2 |
| UniProt Secondary Accession: | Q04695,Q6IP98, Q8N1P6, A5Z1M9, A5Z1N0, A5Z1N1, A5Z1N2 A6NDV6, A6NKQ2, |
| UniProt Related Accession: | Q04695 |
| Molecular Weight: | 48,106 Da |
| NCBI Full Name: | Keratin, type I cytoskeletal 17 |
| NCBI Synonym Full Names: | keratin 17 |
| NCBI Official Symbol: | KRT17 |
| NCBI Official Synonym Symbols: | PC; K17; PC2; 39.1; CK-17; PCHC1 |
| NCBI Protein Information: | keratin, type I cytoskeletal 17 |
| UniProt Protein Name: | Keratin, type I cytoskeletal 17 |
| UniProt Synonym Protein Names: | 39.1; Cytokeratin-17; CK-17; Keratin-17; K17 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT17 |
 | Western blot analysis of extracts of various cell lines, using KRT17 antibody (CAB0123) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded rat kidney using KRT17 antibody (CAB0123) at dilution of 1:200 (40x lens). |
 | Confocal immunofluorescence analysis of HeLa cells using KRT17 antibody (CAB0123) at dilution of 1:200. Blue: DAPI for nuclear staining. |
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