Cell Biology Antibodies 8

Anti-KRT15 Antibody (CAB2660)

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SKU:
CAB2660
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-KRT15 Antibody
Antibody SKU:CAB2660
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human KRT15
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:TE-1, HeLa, SW480, OVCAR-3
Immunogen:Recombinant protein of human KRT15
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3866
Uniprot:P19012
Cellular Location:
Calculated MW:28kDa/49kDa
Observed MW:47-50kDa
Synonyms:KRT15, CK15, K15, K1CO
Background:The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2.
UniProt Protein Function:K15: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytosol; nucleus

Molecular Function:protein binding; structural constituent of cytoskeleton

Biological Process: epidermis development; keratinization

NCBI Summary:The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]
UniProt Code:P19012
NCBI GenInfo Identifier:311033438
NCBI Gene ID:3866
NCBI Accession:P19012.3
UniProt Secondary Accession:P19012,Q53XV8, Q9BUG4, B3KQY1, B3KRA2, E0CX14,
UniProt Related Accession:P19012
Molecular Weight:49kDa
NCBI Full Name:Keratin, type I cytoskeletal 15
NCBI Synonym Full Names:keratin 15
NCBI Official Symbol:KRT15  
NCBI Official Synonym Symbols:K15; CK15; K1CO  
NCBI Protein Information:keratin, type I cytoskeletal 15
UniProt Protein Name:Keratin, type I cytoskeletal 15
UniProt Synonym Protein Names:Cytokeratin-15; CK-15; Keratin-15; K15
Protein Family:Keratin
UniProt Gene Name:KRT15  
Anti-KRT15 Antibody (CAB2660)Western blot analysis of extracts of various cell lines, using KRT15 antibody (CAB2660) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-KRT15 Antibody (CAB2660)Immunohistochemistry of paraffin-embedded human colon carcinoma using KRT15 antibody (CAB2660) at dilution of 1:100 (40x lens).
Anti-KRT15 Antibody (CAB2660)Immunohistochemistry of paraffin-embedded human kidney using KRT15 antibody (CAB2660) at dilution of 1:200 (40x lens).
Anti-KRT15 Antibody (CAB2660)Immunohistochemistry of paraffin-embedded human gastric cancer using KRT15 antibody (CAB2660) at dilution of 1:200 (40x lens).
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