Cell Biology Antibodies 11

Anti-KRT10 Antibody (CAB7908)

(No reviews yet) Write a Review
SKU:
CAB7908
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-KRT10 Antibody
Antibody SKU:CAB7908
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human KRT10
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:H-460
Immunogen:A synthetic peptide of human KRT10
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3858
Uniprot:P13645
Cellular Location:
Calculated MW:58kDa
Observed MW:59kDa
Synonyms:KRT10, BCIE, BIE, CK10, EHK, K10, KPP
Background:This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.
UniProt Protein Function:K10: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K1.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cytoplasm; extracellular space; membrane; nucleus

Biological Process: keratinocyte differentiation

Disease: Epidermolytic Hyperkeratosis; Erythroderma, Ichthyosiform, Congenital Reticular; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis

NCBI Summary:This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
UniProt Code:P13645
NCBI GenInfo Identifier:269849769
NCBI Gene ID:3858
NCBI Accession:P13645.6
UniProt Secondary Accession:P13645,Q14664, Q8N175,
UniProt Related Accession:P13645
Molecular Weight:58,827 Da
NCBI Full Name:Keratin, type I cytoskeletal 10
NCBI Synonym Full Names:keratin 10
NCBI Official Symbol:KRT10  
NCBI Official Synonym Symbols:BIE; EHK; K10; KPP; BCIE; CK10  
NCBI Protein Information:keratin, type I cytoskeletal 10
UniProt Protein Name:Keratin, type I cytoskeletal 10
UniProt Synonym Protein Names:Cytokeratin-10; CK-10; Keratin-10; K10
Protein Family:Keratin
UniProt Gene Name:KRT10  
UniProt Entry Name:K1C10_HUMAN
Anti-KRT10 Antibody (CAB7908)Western blot analysis of extracts of H-460 cells, using KRT10 antibody (CAB7908) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
View AllClose

0 Reviews

View AllClose

Related Products