Antibody Name:	Anti-KRT1 Antibody
Antibody SKU:	CAB16275
Antibody Size:	20uL, 50uL, 100uL
Application:	IHC IF
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 200-450 of human KRT1 (NP_006112.3).

Application:	IHC IF
Recommended Dilution:	IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:	Human, Mouse
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 200-450 of human KRT1 (NP_006112.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	FLEQ QNQV LQTK WELL QQVD TSTR THNL EPYF ESFI NNLR RRVD QLKS DQSR LDSE LKNM QDMV EDYR NKYE DEIN KRTN AENE FVTI KKDV DGAY MTKV DLQA KLDN LQQE IDFL TALY QAEL SQMQ TQIS ETNV ILSM DNNR SLDL DSII AEVK AQYE DIAQ KSKA EAES LYQS KYEE LQIT AGRH GDSV RNSK IEIS ELNR VIQR LRSE IDNV KKQI SNLQ QSIS DAEQ RGEN ALKD AKNK LNDL EDA
Gene ID:	3848
Uniprot:	P04264
Cellular Location:	Cell membrane
Calculated MW:	66kDa
Observed MW:

Synonyms:

KRT1, CK1, EHK, EHK1, EPPK, K1, KRT1A, NEPPK, keratin 1

Background:

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

UniProt Protein Function:	K1: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K10.
UniProt Protein Details:	Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: cytoskeleton; extracellular matrix; extracellular space; membrane; nucleus Molecular Function:carbohydrate binding; protein binding Biological Process: complement activation, lectin pathway; retinal homeostasis Disease: Epidermolytic Hyperkeratosis; Ichthyosis Hystrix, Curth-macklin Type; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis; Keratosis Palmoplantaris Striata Iii; Palmoplantar Keratoderma, Epidermolytic; Palmoplantar Keratoderma, Nonepidermolytic
NCBI Summary:	The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
UniProt Code:	P04264
NCBI GenInfo Identifier:	238054406
NCBI Gene ID:	3848
NCBI Accession:	P04264.6
UniProt Secondary Accession:	P04264,P85925, P86104, Q14720, Q6GSJ0, Q9H298, B2RA01
UniProt Related Accession:	P04264
Molecular Weight:	66,039 Da
NCBI Full Name:	Keratin, type II cytoskeletal 1
NCBI Synonym Full Names:	keratin 1
NCBI Official Symbol:	KRT1
NCBI Official Synonym Symbols:	K1; CK1; EHK; EHK1; EPPK; KRT1A; NEPPK
NCBI Protein Information:	keratin, type II cytoskeletal 1
UniProt Protein Name:	Keratin, type II cytoskeletal 1
UniProt Synonym Protein Names:	67 kDa cytokeratin; Cytokeratin-1; CK-1; Hair alpha protein; Keratin-1; K1; Type-II keratin Kb1
Protein Family:	Keratin
UniProt Gene Name:	KRT1
UniProt Entry Name:	K2C1_HUMAN

	Immunohistochemistry of paraffin-embedded human tonsil using KRT1 antibody (CAB16275) at dilution of 1:100 (40x lens).
	Immunofluorescence analysis of NIH/3T3 cells using KRT1 antibody (CAB16275) at dilution of 1:100. Blue: DAPI for nuclear staining.