Metabolism Antibodies 3

Anti-KREMEN2 Antibody (CAB16202)

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SKU:
CAB16202
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-KREMEN2 Antibody
Antibody SKU:CAB16202
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-360 of human KREMEN2 (NP_078783.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-360 of human KREMEN2 (NP_078783.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GQLC GGDG RLGV YEVS VGSC QGNW TAPQ GVIY SPDF PDEY GPDR NCSW ALGP PGAA LELT FRLF ELAD PRDR LELR DAAS GSLL RAFD GARP PPSG PLRL GTAA LLLT FRSD ARGH AQGF ALTY RGLQ DAAE DPEA PEGS AQTP AAPL DGAN VSCS PRPG A
Gene ID:79412
Uniprot:Q8NCW0
Cellular Location:
Calculated MW:40kDa/42kDa/44kDa/45kDa/48kDa
Observed MW:48kDa
Synonyms:KREMEN2, KRM2
Background:This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
UniProt Protein Function:KREMEN2: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: membrane; early endosome membrane; plasma membrane; integral to membrane

Biological Process: Wnt receptor signaling pathway; cell communication

NCBI Summary:This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:Q8NCW0
NCBI GenInfo Identifier:27437008
NCBI Gene ID:79412
NCBI Accession:NP_757384.1
UniProt Secondary Accession:Q8NCW0,Q8N2J4, Q8NCW1, Q96GL8, Q9BTP9, B4DXF6, I3L2S2
UniProt Related Accession:Q8NCW0
Molecular Weight:40,433 Da
NCBI Full Name:kremen protein 2 isoform d
NCBI Synonym Full Names:kringle containing transmembrane protein 2
NCBI Official Symbol:KREMEN2  
NCBI Official Synonym Symbols:KRM2  
NCBI Protein Information:kremen protein 2
UniProt Protein Name:Kremen protein 2
UniProt Synonym Protein Names:Dickkopf receptor 2; Kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose
Protein Family:Kremen protein
UniProt Gene Name:KREMEN2  
UniProt Entry Name:KREM2_HUMAN
Anti-KREMEN2 Antibody (CAB16202)Western blot analysis of extracts of various cell lines, using KREMEN2 antibody (CAB16202) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s.
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