Cell Cycle Antibodies 1
Anti-KNSTRN Antibody (CAB14306)
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- SKU:
- CAB14306
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-KNSTRN Antibody |
| Antibody SKU: | CAB14306 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human KNSTRN (NP_001136233.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T, HeLa, A-431 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human KNSTRN (NP_001136233.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAP EAPP LDRV FRTT WLST ECDS HPLP PSYR KFLF ETQA ADLA GGTT VAAG NLLN ESEK DCGQ DRRA PGVQ PCRL VTMT SVVK TVYS LQPP SALS GGQP ADTQ TRAT SKSL LPVR SKEV DVSK QLHS GGPE NDVT KITK LRRE NGQM KATD TATR RNVR KGYK PLSK QKSE EELK DKNQ LLEA VNKQ LHQK LTET QGEL KDLT QKVE LLEK FRDN CLAI LESK GLDP ALGS ETLA SRQE STTD HMDS MLLL ETLQ EELK LFNE TAKK QM |
| Gene ID: | 90417 |
| Uniprot: | Q9Y448 |
| Cellular Location: | Chromosome, Cytoplasm, Nucleus, centromere, cytoskeleton, kinetochore, spindle pole |
| Calculated MW: | 26kDa/31kDa/35kDa |
| Observed MW: | 34kDa |
| Synonyms: | KNSTRN, C15orf23, HSD11, SKAP, TRAF4AF1 |
| Background: |
| UniProt Protein Function: | Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). |
| UniProt Code: | Q9Y448 |
| NCBI GenInfo Identifier: | 218505831 |
| NCBI Gene ID: | 90417 |
| NCBI Accession: | NP_001136233.1 |
| UniProt Secondary Accession: | Q9Y448,Q147U5, Q32Q57, Q5ISJ0, Q6P2S5, Q6PJM0, Q86XB4 B4DXA7, |
| UniProt Related Accession: | Q9Y448 |
| Molecular Weight: | 26,586 Da |
| NCBI Full Name: | small kinetochore-associated protein isoform b |
| NCBI Synonym Full Names: | kinetochore localized astrin (SPAG5) binding protein |
| NCBI Official Symbol: | KNSTRN |
| NCBI Official Synonym Symbols: | SKAP; HSD11; C15orf23; TRAF4AF1 |
| NCBI Protein Information: | small kinetochore-associated protein |
| UniProt Protein Name: | Small kinetochore-associated protein |
| UniProt Synonym Protein Names: | Kinetochore-localized astrin-binding protein |
| Protein Family: | Small kinetochore-associated protein |
| UniProt Gene Name: | KNSTRN |
 | Western blot analysis of extracts of various cell lines, using KNSTRN antibody (CAB14306) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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