| UniProt Protein Function: | MLL2: may be a transcriptional regulator. Contains 3 A.T hook DNA-binding domains. Two alternatively spliced isoforms have been described.Protein type: Methyltransferase; EC 2.1.1.43; Transcription factor; Methyltransferase, protein lysine; DNA-bindingChromosomal Location of Human Ortholog: 19q13.1Cellular Component: nucleoplasm; histone methyltransferase complex; nucleusMolecular Function: protein binding; DNA binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); transcription factor activityBiological Process: ovulation; establishment and/or maintenance of chromatin architecture; ovarian follicle development; transcription, DNA-dependent; chromatin-mediated maintenance of transcription; histone H3-K4 methylation; oocyte differentiation; regulation of histone H3-K4 methylation; gene silencing |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UMN6 |
| NCBI GenInfo Identifier: | 7662046 |
| NCBI Gene ID: | 9757 |
| NCBI Accession: | NP_055542.1 |
| UniProt Secondary Accession: | Q9UMN6,O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668 Q9Y669 |
| UniProt Related Accession: | Q9UMN6 |
| Molecular Weight: | |
| NCBI Full Name: | histone-lysine N-methyltransferase 2B |
| NCBI Synonym Full Names: | lysine (K)-specific methyltransferase 2B |
| NCBI Official Symbol: | KMT2B |
| NCBI Official Synonym Symbols: | HRX2; MLL2; MLL4; TRX2; WBP7; MLL1B; WBP-7 |
| NCBI Protein Information: | histone-lysine N-methyltransferase 2B; trithorax homologue 2; WW domain binding protein 7; mixed lineage leukemia gene homolog 2; histone-lysine N-methyltransferase MLL4; myeloid/lymphoid or mixed-lineage leukemia protein 4; myeloid/lymphoid or mixed-line |
| UniProt Protein Name: | Histone-lysine N-methyltransferase 2B |
| UniProt Synonym Protein Names: | Myeloid/lymphoid or mixed-lineage leukemia protein 4; Trithorax homolog 2; WW domain-binding protein 7; WBP-7 |
| Protein Family: | |
| UniProt Gene Name: | KMT2B |
| UniProt Entry Name: | KMT2B_HUMAN |
