Cell Biology Antibodies 3
Anti-KLRD1 Antibody (CAB12698)
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- SKU:
- CAB12698
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-KLRD1 Antibody |
| Antibody SKU: | CAB12698 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-179 of human KLRD1 (NP_002253.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-179 of human KLRD1 (NP_002253.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KNSF TKLS IEPA FTPG PNIE LQKD SDCC SCQE KWVG YRCN CYFI SSEQ KTWN ESRH LCAS QKSS LLQL QNTD ELDF MSSS QQFY WIGL SYSE EHTA WLWE NGSA LSQY LFPS FETF NTKN CIAY NPNG NALD ESCE DKNR YICK QQLI |
| Gene ID: | 3824 |
| Uniprot: | Q13241 |
| Cellular Location: | Membrane, Single-pass type II membrane protein |
| Calculated MW: | 17kDa/20kDa |
| Observed MW: | 40kDa |
| Synonyms: | KLRD1, CD94 |
| Background: | Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. |
| UniProt Protein Function: | KLRD1: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13 Cellular Component: integral to membrane; plasma membrane; receptor complex; external side of plasma membrane Molecular Function:protein binding; transmembrane receptor activity; carbohydrate binding Biological Process: regulation of immune response; cell surface receptor linked signal transduction; natural killer cell mediated immunity; innate immune response |
| NCBI Summary: | Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017] |
| UniProt Code: | Q13241 |
| NCBI GenInfo Identifier: | 334302835 |
| NCBI Gene ID: | 3824 |
| NCBI Accession: | Q13241.2 |
| UniProt Related Accession: | Q13241 |
| Molecular Weight: | |
| NCBI Full Name: | Natural killer cells antigen CD94 |
| NCBI Synonym Full Names: | killer cell lectin like receptor D1 |
| NCBI Official Symbol: | KLRD1 |
| NCBI Official Synonym Symbols: | CD94 |
| NCBI Protein Information: | natural killer cells antigen CD94 |
| UniProt Protein Name: | Natural killer cells antigen CD94 |
| UniProt Synonym Protein Names: | KP43; Killer cell lectin-like receptor subfamily D member 1; NK cell receptor; CD_antigen: CD94 |
| UniProt Gene Name: | KLRD1 |
| UniProt Entry Name: | KLRD1_HUMAN |
 | Western blot analysis of extracts of mouse brain, using KLRD1 antibody (CAB12698) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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