Cell Biology Antibodies 5

Anti-KLRC4 Antibody (CAB14807)

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SKU:
CAB14807
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-KLRC4 Antibody
Antibody SKU:CAB14807
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-55 of human KLRC4 (NP_038459.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, NCI-H460, 293T, Mouse lung, Mouse kidney, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-55 of human KLRC4 (NP_038459.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNKQ RGTY SEVS LAQD PKRQ QRKL KGNK ISIS GTKQ EIFQ VELN LQNA SSDH QGN
Gene ID:8302
Uniprot:O43908
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:18kDa
Observed MW:14kDa
Synonyms:KLRC4, NKG2-F, NKG2F
Background:Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member.
UniProt Protein Function:KLRC4: May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2-p12.3

Cellular Component: integral to membrane

Biological Process: cellular defense response

NCBI Summary:Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010]
UniProt Code:O43908
NCBI GenInfo Identifier:7710124
NCBI Gene ID:8302
NCBI Accession:NP_038459.1
UniProt Secondary Accession:O43908,O60851,
UniProt Related Accession:O43908
Molecular Weight:18,234 Da
NCBI Full Name:NKG2-F type II integral membrane protein
NCBI Synonym Full Names:killer cell lectin like receptor C4
NCBI Official Symbol:KLRC4  
NCBI Official Synonym Symbols:NKG2F; NKG2-F  
NCBI Protein Information:NKG2-F type II integral membrane protein
UniProt Protein Name:NKG2-F type II integral membrane protein
UniProt Synonym Protein Names:NK cell receptor F; NKG2-F-activating NK receptor
Protein Family:NKG2-F type II integral membrane protein
UniProt Gene Name:KLRC4  
UniProt Entry Name:NKG2F_HUMAN
Anti-KLRC4 Antibody (CAB14807)Western blot analysis of extracts of various cell lines, using KLRC4 antibody (CAB14807) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-KLRC4 Antibody (CAB14807)Immunofluorescence analysis of Jurkat cells using KLRC4 Polyclonal Antibody (CAB14807) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Anti-KLRC4 Antibody (CAB14807)Immunofluorescence analysis of mouse spleen using KLRC4 Polyclonal Antibody (CAB14807) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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