Cell Biology Antibodies 4

Anti-KLRC1 Antibody (CAB14014)

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SKU:
CAB14014
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-KLRC1 Antibody
Antibody SKU:CAB14014
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 96-215 of human KLRC1 (NP_015567.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 96-215 of human KLRC1 (NP_015567.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RHCG HCPE EWIT YSNS CYYI GKER RTWE ESLL ACTS KNSS LLSI DNEE EMKF LSII SPSS WIGV FRNS SHHP WVTM NGLA FKHE IKDS DNAE LNCA VLQV NRLK SAQC GSSI IYHC KHKL
Gene ID:3821
Uniprot:P26715
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:24kDa/26kDa
Observed MW:Refer to figures
Synonyms:KLRC1, CD159A, NKG2, NKG2A
Background:Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
UniProt Protein Function:Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
NCBI Summary:Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]
UniProt Code:P26715
NCBI GenInfo Identifier:317373399
NCBI Gene ID:3821
NCBI Accession:P26715.2
UniProt Related Accession:P26715
Molecular Weight:24,250 Da
NCBI Full Name:NKG2-A/NKG2-B type II integral membrane protein
NCBI Synonym Full Names:killer cell lectin like receptor C1
NCBI Official Symbol:KLRC1  
NCBI Official Synonym Symbols:NKG2; NKG2A; CD159A  
NCBI Protein Information:NKG2-A/NKG2-B type II integral membrane protein
UniProt Protein Name:NKG2-A/NKG2-B type II integral membrane protein
UniProt Synonym Protein Names:CD159 antigen-like family member A; NK cell receptor A; NKG2-A/B-activating NK receptor; CD_antigen: CD159a
UniProt Gene Name:KLRC1  
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