Cell Biology Antibodies 2
Anti-KLRB1 Antibody (CAB11783)
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- SKU:
- CAB11783
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-KLRB1 Antibody |
| Antibody SKU: | CAB11783 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 73-140 of human KLRB1 (NP_002249.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | THP-1, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 73-140 of human KLRB1 (NP_002249.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KCSV DIQQ SRNK TTER PGLL NCPI YWQQ LREK CLLF SHTV NPWN NSLA DCST KESS LLLI RDKD ELIH |
| Gene ID: | 3820 |
| Uniprot: | Q12918 |
| Cellular Location: | Membrane, Single-pass type II membrane protein |
| Calculated MW: | 25kDa |
| Observed MW: | 45kDa |
| Synonyms: | KLRB1, CD161, CLEC5B, NKR, NKR-P1, NKR-P1A, NKRP1A, hNKR-P1A |
| Background: | Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. |
| UniProt Protein Function: | Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. |
| NCBI Summary: | Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q12918 |
| NCBI GenInfo Identifier: | 74722301 |
| NCBI Gene ID: | 3820 |
| NCBI Accession: | Q12918.1 |
| UniProt Secondary Accession: | Q12918,Q24K24, |
| UniProt Related Accession: | Q12918 |
| Molecular Weight: | 25,415 Da |
| NCBI Full Name: | Killer cell lectin-like receptor subfamily B member 1 |
| NCBI Synonym Full Names: | killer cell lectin like receptor B1 |
| NCBI Official Symbol: | KLRB1 |
| NCBI Official Synonym Symbols: | NKR; CD161; CLEC5B; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A |
| NCBI Protein Information: | killer cell lectin-like receptor subfamily B member 1 |
| UniProt Protein Name: | Killer cell lectin-like receptor subfamily B member 1 |
| UniProt Synonym Protein Names: | C-type lectin domain family 5 member B; HNKR-P1a; NKR-P1A; Natural killer cell surface protein P1A; CD_antigen: CD161 |
| Protein Family: | Killer cell lectin-like receptor subfamily |
| UniProt Gene Name: | KLRB1 |
 | Western blot analysis of extracts of various cell lines, using KLRB1 antibody (CAB11783) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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