Cell Biology Antibodies 8
Anti-KLK5 Antibody (CAB2991)
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- SKU:
- CAB2991
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-KLK5 Antibody |
| Antibody SKU: | CAB2991 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human KLK5 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse testis, Mouse heart, Mouse liver |
| Immunogen: | A synthetic peptide of human KLK5 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 25818 |
| Uniprot: | Q9Y337 |
| Cellular Location: | Secreted |
| Calculated MW: | 32kDa |
| Observed MW: | 32kDa |
| Synonyms: | KLK5, KLK-L2, KLKL2, SCTE |
| Background: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. |
| UniProt Protein Function: | KLK5: May be involved in desquamation. Belongs to the peptidase S1 family. Kallikrein subfamily. |
| UniProt Protein Details: | Protein type:EC 3.4.21.-; Protease; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: extracellular space Molecular Function:peptidase activity; protein binding; serine-type peptidase activity; serine-type endopeptidase activity Biological Process: epidermis development; positive regulation of G-protein coupled receptor protein signaling pathway; proteolysis |
| NCBI Summary: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y337 |
| NCBI GenInfo Identifier: | 296434569 |
| NCBI Gene ID: | 25818 |
| NCBI Accession: | Q9Y337.2 |
| UniProt Secondary Accession: | Q9Y337,Q53ZR3, Q9HBG8, |
| UniProt Related Accession: | Q9Y337 |
| Molecular Weight: | 293 |
| NCBI Full Name: | Kallikrein-5 |
| NCBI Synonym Full Names: | kallikrein-related peptidase 5 |
| NCBI Official Symbol: | KLK5 |
| NCBI Official Synonym Symbols: | SCTE; KLKL2; KLK-L2 |
| NCBI Protein Information: | kallikrein-5; kallikrein 5; kallikrein-like protein 2; stratum corneum tryptic enzyme |
| UniProt Protein Name: | Kallikrein-5 |
| UniProt Synonym Protein Names: | Kallikrein-like protein 2; KLK-L2; Stratum corneum tryptic enzyme |
| Protein Family: | Kallikrein |
| UniProt Gene Name: | KLK5 |
| UniProt Entry Name: | KLK5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KLK5 antibody (CAB2991) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using KLK5 antibody (CAB2991) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver cancer using KLK5 antibody (CAB2991) at dilution of 1:200 (40x lens). |
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