Cell Biology Antibodies 2

Anti-KLK2 Antibody (CAB12268)

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SKU:
CAB12268
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-KLK2 Antibody
Antibody SKU:CAB12268
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-250 of human KLK2 (NP_005542.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-250 of human KLK2 (NP_005542.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IVGG WECE KHSQ PWQV AVYS HGWA HCGG VLVH PQWV LTAA HCLK KNSQ VWLG RHNL FEPE DTGQ RVPV SHSF PHPL YNMS LLKH QSLR PDED SSHD LMLL RLSE PAKI TDVV KVLG LPTQ EPAL GTTC YASG WGSI EPEE FLRP RSLQ CVSL HLLS NDMC ARAY SEKV TEFM LCAG LWTG GKDT CGGD SGGP LVCN GVLQ GITS WGPE PCAL PEKP AVYT KVVH YR
Gene ID:3817
Uniprot:P20151
Cellular Location:
Calculated MW:17kDa/18kDa/24kDa/28kDa
Observed MW:Refer to figures
Synonyms:KLK2, KLK2A2, hGK-1, hK2
Background:This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants.
UniProt Protein Function:KLK2: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.21.35; Protease

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: extracellular region

Molecular Function:serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis

NCBI Summary:This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
UniProt Code:P20151
NCBI GenInfo Identifier:125174
NCBI Gene ID:3817
NCBI Accession:P20151.1
UniProt Secondary Accession:P20151,Q15946, Q9UJZ9, B4DU93, B4DUB0, F5H8L3,
UniProt Related Accession:P20151
Molecular Weight:261
NCBI Full Name:Kallikrein-2
NCBI Synonym Full Names:kallikrein-related peptidase 2
NCBI Official Symbol:KLK2  
NCBI Official Synonym Symbols:hK2; hGK-1; KLK2A2  
NCBI Protein Information:kallikrein-2; tissue kallikrein-2; glandular kallikrein 2; glandular kallikrein-1; kallikrein 2, prostatic
UniProt Protein Name:Kallikrein-2
UniProt Synonym Protein Names:Glandular kallikrein-1; hGK-1; Tissue kallikrein-2
Protein Family:Kallikrein
UniProt Gene Name:KLK2  
UniProt Entry Name:KLK2_HUMAN
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