Cell Biology Antibodies 2
Anti-KLK2 Antibody (CAB12268)
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- SKU:
- CAB12268
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-KLK2 Antibody |
| Antibody SKU: | CAB12268 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-250 of human KLK2 (NP_005542.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-250 of human KLK2 (NP_005542.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IVGG WECE KHSQ PWQV AVYS HGWA HCGG VLVH PQWV LTAA HCLK KNSQ VWLG RHNL FEPE DTGQ RVPV SHSF PHPL YNMS LLKH QSLR PDED SSHD LMLL RLSE PAKI TDVV KVLG LPTQ EPAL GTTC YASG WGSI EPEE FLRP RSLQ CVSL HLLS NDMC ARAY SEKV TEFM LCAG LWTG GKDT CGGD SGGP LVCN GVLQ GITS WGPE PCAL PEKP AVYT KVVH YR |
| Gene ID: | 3817 |
| Uniprot: | P20151 |
| Cellular Location: | |
| Calculated MW: | 17kDa/18kDa/24kDa/28kDa |
| Observed MW: | Refer to figures |
| Synonyms: | KLK2, KLK2A2, hGK-1, hK2 |
| Background: | This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. |
| UniProt Protein Function: | KLK2: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.21.35; Protease Chromosomal Location of Human Ortholog: 19q13.41 Cellular Component: extracellular region Molecular Function:serine-type endopeptidase activity Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis |
| NCBI Summary: | This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P20151 |
| NCBI GenInfo Identifier: | 125174 |
| NCBI Gene ID: | 3817 |
| NCBI Accession: | P20151.1 |
| UniProt Secondary Accession: | P20151,Q15946, Q9UJZ9, B4DU93, B4DUB0, F5H8L3, |
| UniProt Related Accession: | P20151 |
| Molecular Weight: | 261 |
| NCBI Full Name: | Kallikrein-2 |
| NCBI Synonym Full Names: | kallikrein-related peptidase 2 |
| NCBI Official Symbol: | KLK2 |
| NCBI Official Synonym Symbols: | hK2; hGK-1; KLK2A2 |
| NCBI Protein Information: | kallikrein-2; tissue kallikrein-2; glandular kallikrein 2; glandular kallikrein-1; kallikrein 2, prostatic |
| UniProt Protein Name: | Kallikrein-2 |
| UniProt Synonym Protein Names: | Glandular kallikrein-1; hGK-1; Tissue kallikrein-2 |
| Protein Family: | Kallikrein |
| UniProt Gene Name: | KLK2 |
| UniProt Entry Name: | KLK2_HUMAN |
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