Cell Biology Antibodies 2

Anti-KLK14 Antibody (CAB10767)

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SKU:
CAB10767
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-KLK14 Antibody
Antibody SKU:CAB10767
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 41-267 of human KLK14 (NP_071329.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse stomach
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 41-267 of human KLK14 (NP_071329.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IIGG HTCT RSSQ PWQA ALLA GPRR RFLC GGAL LSGQ WVIT AAHC GRPI LQVA LGKH NLRR WEAT QQVL RVVR QVTH PNYN SRTH DNDL MLLQ LQQP ARIG RAVR PIEV TQAC ASPG TSCR VSGW GTIS SPIA RYPA SLQC VNIN ISPD EVCQ KAYP RTIT PGMV CAGV PQGG KDSC QGDS GGPL VCRG QLQG LVSW GMER CALP GYPG VYTN LCKY RSWI EETM RDK
Gene ID:43847
Uniprot:Q9P0G3
Cellular Location:Secreted, extracellular space
Calculated MW:29kDa
Observed MW:29kDa
Synonyms:KLK14, KLK-L6
Background:This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:KLK14: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. Belongs to the peptidase S1 family. Kallikrein subfamily.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Protease; EC 3.4.21.-; Secreted

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: extracellular space

Molecular Function:serine-type endopeptidase activity

Biological Process: epidermis morphogenesis; fertilization; negative regulation of G-protein coupled receptor protein signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; proteolysis

NCBI Summary:This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
UniProt Code:Q9P0G3
NCBI GenInfo Identifier:251757292
NCBI Gene ID:43847
NCBI Accession:Q9P0G3.2
UniProt Secondary Accession:Q9P0G3,Q1RMZ2, Q6B089, A7UNK5,
UniProt Related Accession:Q9P0G3
Molecular Weight:29,122 Da
NCBI Full Name:Kallikrein-14
NCBI Synonym Full Names:kallikrein related peptidase 14
NCBI Official Symbol:KLK14  
NCBI Official Synonym Symbols:KLK-L6  
NCBI Protein Information:kallikrein-14
UniProt Protein Name:Kallikrein-14
UniProt Synonym Protein Names:Kallikrein-like protein 6; KLK-L6
Protein Family:Kallikrein
UniProt Gene Name:KLK14  
UniProt Entry Name:KLK14_HUMAN
Anti-KLK14 Antibody (CAB10767)Western blot analysis of extracts of mouse stomach, using KLK14 antibody (CAB10767) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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