Cell Biology Antibodies 4
Anti-KLK13 Antibody (CAB14274)
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- SKU:
- CAB14274
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-KLK13 Antibody |
| Antibody SKU: | CAB14274 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human KLK13 (NP_056411.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | DU145, A-431, HeLa, Mouse uterus, Rat uterus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human KLK13 (NP_056411.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MWPL ALVI ASLT LALS GGVS QESS KVLN TNGT SGFL PGGY TCFP HSQP WQAA LLVQ GRLL CGGV LVHP KWVL TAAH CLKE GLKV YLGK HALG RVEA GEQV REVV HSIP HPEY RRSP THLN HDHD IMLL ELQS PVQL TGYI QTLP LSHN NRLT PGTT CRVS GWGT TTSP QVNY PKTL QCAN IQLR SDEE CRQV YPGK ITDN MLCA GTKE GGKD SCEG DSGG PLVC NRTL YGIV SWGD FPCG QPDR PGVY TRVS RYVL WIRE TIRK YETQ QQKW LKGP Q |
| Gene ID: | 26085 |
| Uniprot: | Q9UKR3 |
| Cellular Location: | Secreted |
| Calculated MW: | 13kDa/30kDa |
| Observed MW: | 30kDa |
| Synonyms: | KLK13, KLK-L4, KLKL4 |
| Background: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. |
| UniProt Protein Function: | KLK13: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Vesicle; Secreted; Secreted, signal peptide; Protease; EC 3.4.21.- Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: extracellular space; cytoplasm; extracellular region; secretory granule Molecular Function:protein binding; hydrolase activity; serine-type endopeptidase activity Biological Process: protein processing; proteolysis |
| NCBI Summary: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UKR3 |
| NCBI GenInfo Identifier: | 11496281 |
| NCBI Gene ID: | 26085 |
| NCBI Accession: | NP_056411.1 |
| UniProt Secondary Accession: | Q9UKR3,Q86VI8, Q9Y433, A7UNK6, |
| UniProt Related Accession: | Q9UKR3 |
| Molecular Weight: | 13,986 Da |
| NCBI Full Name: | kallikrein-13 |
| NCBI Synonym Full Names: | kallikrein-related peptidase 13 |
| NCBI Official Symbol: | KLK13 |
| NCBI Official Synonym Symbols: | KLKL4; KLK-L4 |
| NCBI Protein Information: | kallikrein-13; kallikrein 13; kallikrein-like gene 4; kallikrein-like protein 4 |
| UniProt Protein Name: | Kallikrein-13 |
| UniProt Synonym Protein Names: | Kallikrein-like protein 4; KLK-L4 |
| Protein Family: | Kallikrein |
| UniProt Gene Name: | KLK13 |
| UniProt Entry Name: | KLK13_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KLK13 antibody (CAB14274) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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