Cell Biology Antibodies 7

Anti-KLK12 Antibody (CAB16523)

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SKU:
CAB16523
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-KLK12 Antibody
Antibody SKU:CAB16523
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 18-150 of human KLK12 (NP_062544.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 18-150 of human KLK12 (NP_062544.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ATPK IFNG TECG RNSQ PWQV GLFE GTSL RCGG VLID HRWV LTAA HCSG SRYW VRLG EHSL SQLD WTEQ IRHS GFSV THPG YLGA STSH EHDL RLLR LRLP VRVT SSVQ PLPL PNDC ATAG TECH VSGW GITN H
Gene ID:43849
Uniprot:Q9UKR0
Cellular Location:Secreted
Calculated MW:11kDa/26kDa/27kDa
Observed MW:28kDa
Synonyms:KLK12, KLK-L5, KLKL5
Background:Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.
UniProt Protein Function:KLK12: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:EC 3.4.21.-; Secreted; Protease; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.33

Molecular Function:peptidase activity; serine-type peptidase activity

Biological Process: proteolysis

NCBI Summary:Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UKR0
NCBI GenInfo Identifier:9296989
NCBI Gene ID:43849
NCBI Accession:Q9UKR0.1
UniProt Secondary Accession:Q9UKR0,Q9UKR1, Q9UKR2,
UniProt Related Accession:Q9UKR0
Molecular Weight:11,984 Da
NCBI Full Name:Kallikrein-12
NCBI Synonym Full Names:kallikrein related peptidase 12
NCBI Official Symbol:KLK12  
NCBI Official Synonym Symbols:KLKL5; KLK-L5  
NCBI Protein Information:kallikrein-12
UniProt Protein Name:Kallikrein-12
UniProt Synonym Protein Names:Kallikrein-like protein 5; KLK-L5
Protein Family:Kallikrein
UniProt Gene Name:KLK12  
UniProt Entry Name:KLK12_HUMAN
Anti-KLK12 Antibody (CAB16523)Western blot analysis of extracts of HeLa cells, using KLK12 antibody (CAB16523) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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