Cell Biology Antibodies 7

Anti-KLK1 Antibody (CAB1807)

(No reviews yet) Write a Review
SKU:
CAB1807
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-KLK1 Antibody
Antibody SKU:CAB1807
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-262 of human KLK1 (NP_002248.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:SW480, K-562
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-262 of human KLK1 (NP_002248.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IVGG WECE QHSQ PWQA ALYH FSTF QCGG ILVH RQWV LTAA HCIS DNYQ LWLG RHNL FDDE NTAQ FVHV SESF PHPG FNMS LLEN HTRQ ADED YSHD LMLL RLTE PADT ITDA VKVV ELPT EEPE VGST CLAS GWGS IEPE NFSF PDDL QCVD LKIL PNDE CKKA HVQK VTDF MLCV GHLE GGKD TCVG DSGG PLMC DGVL QGVT SWGY VPCG TPNK PSVA VRVL SYVK WIED TIAE NS
Gene ID:3816
Uniprot:P06870
Cellular Location:
Calculated MW:23kDa/28kDa
Observed MW:22kDa
Synonyms:KLK1, KLKR, Klk6, hK1
Background:Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.
UniProt Protein Function:KLK1: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protease; EC 3.4.21.35

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: nucleus

Molecular Function:serine-type endopeptidase activity

Biological Process: proteolysis

Disease: Kallikrein, Decreased Urinary Activity Of

NCBI Summary:Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]
UniProt Code:P06870
NCBI GenInfo Identifier:269849612
NCBI Gene ID:3816
NCBI Accession:P06870.2
UniProt Secondary Accession:P06870,Q66US9, Q86U61, Q8TCV8, Q9BS53, Q9NQU4, Q9UD19 Q9UMJ1,
UniProt Related Accession:P06870
Molecular Weight:23,835 Da
NCBI Full Name:Kallikrein-1
NCBI Synonym Full Names:kallikrein 1
NCBI Official Symbol:KLK1  
NCBI Official Synonym Symbols:hK1; KLKR; Klk6  
NCBI Protein Information:kallikrein-1; tissue kallikrein; glandular kallikrein 1; kallikrein serine protease 1; kallikrein 1, renal/pancreas/salivary; kidney/pancreas/salivary gland kallikrein
UniProt Protein Name:Kallikrein-1
UniProt Synonym Protein Names:Kidney/pancreas/salivary gland kallikrein; Tissue kallikrein
Protein Family:Kallikrein 1-related peptidase
UniProt Gene Name:KLK1  
UniProt Entry Name:KLK1_HUMAN
Anti-KLK1 Antibody (CAB1807)Western blot analysis of extracts of various cell lines, using KLK1 antibody (CAB1807) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
View AllClose

0 Reviews

View AllClose

Related Products