Cell Biology Antibodies 6

Anti-KLHL41 Antibody (CAB15383)

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SKU:
CAB15383
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-KLHL41 Antibody
Antibody SKU:CAB15383
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human KLHL41 (NP_006054.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, Mouse heart, Mouse skeletal muscle, Rat skeletal muscle
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human KLHL41 (NP_006054.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDSQ RELA EELR LYQS TLLQ DGLK DLLD EKKF IDCT LKAG DKSL PCHR LILS ACSP YFRE YFLS EIDE AKKK EVVL DNVD PAIL DLII KYLY SASI DLND GNVQ DIFA LASR FQIP SVFT VCVS YLQK RLAP GNCL AILR LGLL LDCP RLAI SARE FVSD RFVQ ICKE EDFM QLSP QELI SVIS NDSL NVEK EEAV FEAV MKWV RTDK ENRV KNLS EVFD CIRF RLMT EKYF KDHV EKDD IIKS NPDL QKKI KVLK DAFA GKLP EPSK NAAK TGAG EVNG DVGD EDLL PGYL NDIP RHGM
Gene ID:10324
Uniprot:O60662
Cellular Location:Cell projection, Cytoplasm, Endoplasmic reticulum membrane, M line, Sarcoplasmic reticulum membrane, cytoskeleton, myofibril, pseudopodium, ruffle, sarcomere
Calculated MW:66kDa/68kDa
Observed MW:68kDa
Synonyms:KLHL41, KBTBD10, Krp1, SARCOSIN
Background:This gene is a member of the kelch-like family. The encoded protein contains a BACK domain, a BTB/POZ domain, and 5 Kelch repeats. This protein is thought to function in skeletal muscle development and maintenance. Mutations in this gene have been associated with nemaline myopathy (NM), a rare congenital muscle disorder.
UniProt Protein Function:KBTBD10: Required for pseudopod elongation in transformed cells. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytoskeletal; Ubiquitin conjugating system; Contractile; Cell adhesion

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: cytoplasm; cytoskeleton; endoplasmic reticulum membrane; M band; nucleus; plasma membrane; sarcoplasmic reticulum membrane

Molecular Function:protein binding; ubiquitin-protein ligase activity

Biological Process: myofibril assembly; protein ubiquitination; regulation of myoblast differentiation; sarcomere organization; skeletal muscle fiber development; striated muscle contraction

Disease: Nemaline Myopathy 9

NCBI Summary:This gene is a member of the kelch-like family. The encoded protein contains a BACK domain, a BTB/POZ domain, and 5 Kelch repeats. This protein is thought to function in skeletal muscle development and maintenance. Mutations in this gene have been associated with nemaline myopathy (NM), a rare congenital muscle disorder. [provided by RefSeq, Mar 2015]
UniProt Code:O60662
NCBI GenInfo Identifier:14285509
NCBI Gene ID:10324
NCBI Accession:O60662.2
UniProt Secondary Accession:O60662,Q53R42,
UniProt Related Accession:O60662
Molecular Weight:66,866 Da
NCBI Full Name:Kelch-like protein 41
NCBI Synonym Full Names:kelch like family member 41
NCBI Official Symbol:KLHL41  
NCBI Official Synonym Symbols:Krp1; KBTBD10; SARCOSIN  
NCBI Protein Information:kelch-like protein 41
UniProt Protein Name:Kelch-like protein 41
UniProt Synonym Protein Names:Kel-like protein 23; Kelch repeat and BTB domain-containing protein 10; Kelch-related protein 1; Sarcosin
Protein Family:Kelch-like protein
UniProt Gene Name:KLHL41  
UniProt Entry Name:KLH41_HUMAN
Anti-KLHL41 Antibody (CAB15383)Western blot analysis of extracts of various cell lines, using KLHL41 antibody (CAB15383) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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