Cell Cycle Antibodies 2

Anti-KLHL13 Antibody (CAB9989)

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SKU:
CAB9989
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-KLHL13 Antibody
Antibody SKU:CAB9989
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human KLHL13 (NP_277030.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Jurkat, HeLa, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human KLHL13 (NP_277030.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPLK WKTS SPAI WKFP VPVL KTSR STPL SPAY ISLV EEED QHMK LSLG GSEM GLSS HLQS SKAG PTRI FTSN THSS VVLQ GFDQ LRLE GLLC DVTL MPGD TDDA FPVH RVMM ASAS DYFK AMFT GGMK EQDL MCIK LHGV SKVG LRKI IDFI YTAK LSLN MDNL QDTL EAAS FLQI LPVL DFCK VFLI SGVT LDNC VEVG RIAN TYNL TEVD KYVN SFVL KNFP ALLS TGEF LKLP FERL AFVL SSNS LKHC TELE LFKA
Gene ID:90293
Uniprot:Q9P2N7
Cellular Location:
Calculated MW:69kDa/72kDa/73kDa/74kDa
Observed MW:60kDa
Synonyms:KLHL13, BKLHD2
Background:This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:KLHL13: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: Xq23-q24

Molecular Function:ubiquitin-protein ligase activity

Biological Process: mitosis; cytokinesis; protein ubiquitination

NCBI Summary:This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
UniProt Code:Q9P2N7
NCBI GenInfo Identifier:269973869
NCBI Gene ID:90293
NCBI Accession:NP_001161774.1
UniProt Secondary Accession:Q9P2N7,Q6P2E3, Q96QI7, Q9UDN9, B3KV78, B3KWM7, B7Z3S9 B7Z5P2, B7Z802, D3DWH6,
UniProt Related Accession:Q9P2N7
Molecular Weight:74,630 Da
NCBI Full Name:kelch-like protein 13 isoform d
NCBI Synonym Full Names:kelch-like family member 13
NCBI Official Symbol:KLHL13  
NCBI Official Synonym Symbols:BKLHD2  
NCBI Protein Information:kelch-like protein 13; kelch-like 13; BTB and kelch domain containing 2
UniProt Protein Name:Kelch-like protein 13
UniProt Synonym Protein Names:BTB and kelch domain-containing protein 2
Protein Family:Kelch-like protein
UniProt Gene Name:KLHL13  
UniProt Entry Name:KLH13_HUMAN
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