Epigenetics & Nuclear Signaling Antibodies 4

Anti-KLF7 Antibody (CAB8879)

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SKU:
CAB8879
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-KLF7 Antibody
Antibody SKU:CAB8879
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 51-230 of human KLF7 (NP_001257871.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, 22Rv1, K-562, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 51-230 of human KLF7 (NP_001257871.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SETF GEDL DCFL HASP PPCI EESF RRLD PLLL PVEA AICE KSSA VDIL LSRD KLLS ETCL SLQP ASSS LDSY TAVN QAQL NAVT SLTP PSSP ELSR HLVK TSQT LSAV DGTV TLKL VAKK AALS SVKV RSLI SAHG RDVS GVLH EAMS SRGT TGNT QVQS PSNA TTAT GVFP GLTI LPST
Gene ID:8609
Uniprot:O75840
Cellular Location:Nucleus
Calculated MW:9kDa/13kDa/24kDa/29kDa/30kDa/33kDa
Observed MW:37kDa
Synonyms:KLF7, UKLF
Background:The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:KLF7: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence. Belongs to the krueppel C2H2-type zinc-finger protein family.
UniProt Protein Details:

Protein type:DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: nucleus

Molecular Function:DNA binding; zinc ion binding; transcription coactivator activity; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; axon guidance; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; dendrite morphogenesis

NCBI Summary:The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Code:O75840
NCBI GenInfo Identifier:401709918
NCBI Gene ID:8609
NCBI Accession:NP_001257871.1
UniProt Secondary Accession:O75840,Q7Z3H8, Q96E51, B2RB03, B7Z4F7, C9JF04, E7EWH1 L0R4P2,
UniProt Related Accession:O75840
Molecular Weight:33kd
NCBI Full Name:Krueppel-like factor 7 isoform 2
NCBI Synonym Full Names:Kruppel-like factor 7 (ubiquitous)
NCBI Official Symbol:KLF7  
NCBI Official Synonym Symbols:UKLF  
NCBI Protein Information:Krueppel-like factor 7
UniProt Protein Name:Krueppel-like factor 7
UniProt Synonym Protein Names:Ubiquitous krueppel-like factor
Protein Family:Krueppel-like factor
UniProt Gene Name:KLF7  
UniProt Entry Name:KLF7_HUMAN
Anti-KLF7 Polyclonal Antibody (CAB8879)Western blot analysis of extracts of various cell lines, using KLF7 antibody (CAB8879) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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