| UniProt Protein Function: | KLF12: Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; C2H2-type zinc finger protein; DNA-binding Chromosomal Location of Human Ortholog: 13q22 Cellular Component: nucleus Molecular Function: DNA binding; metal ion binding; transcription corepressor activity; transcription factor activity Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter |
| UniProt Protein Details: | |
| NCBI Summary: | Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y4X4 |
| NCBI GenInfo Identifier: | 91771555 |
| NCBI Gene ID: | 11278 |
| NCBI Accession: | Q9Y4X4.2 |
| UniProt Secondary Accession: | Q9Y4X4,Q5VZM7, Q9UHZ0, A8K5T2, L0R3J4 |
| UniProt Related Accession: | Q9Y4X4 |
| Molecular Weight: | 402 |
| NCBI Full Name: | Krueppel-like factor 12 |
| NCBI Synonym Full Names: | Kruppel-like factor 12 |
| NCBI Official Symbol: | KLF12 |
| NCBI Official Synonym Symbols: | AP2REP; AP-2rep; HSPC122 |
| NCBI Protein Information: | Krueppel-like factor 12; AP-2 repressor; AP-2rep transcription factor; transcriptional repressor AP-2rep; KLF12 zinc finger transcriptional repressor |
| UniProt Protein Name: | Krueppel-like factor 12 |
| UniProt Synonym Protein Names: | Transcriptional repressor AP-2rep |
| Protein Family: | Krueppel-like factor |
| UniProt Gene Name: | KLF12 |
| UniProt Entry Name: | KLF12_HUMAN |
