Cell Biology Antibodies 16
Anti-KLC2 Antibody (CAB17757)
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- SKU:
- CAB17757
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-KLC2 Antibody |
| Antibody SKU: | CAB17757 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KLC2 (NP_073733.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji, Mouse brain, Rat lung, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KLC2 (NP_073733.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAMM VFPR EEKL SQDE IVLG TKAV IQGL ETLR GEHR ALLA PLVA PEAG EAEP GSQE RCIL LRRS LEAI ELGL GEAQ VILA LSSH LGAV ES |
| Gene ID: | 64837 |
| Uniprot: | Q9H0B6 |
| Cellular Location: | |
| Calculated MW: | 60kDa/68kDa |
| Observed MW: | 69kDa |
 | Western blot - KLC2 Polyclonal Antibody (CAB17757) |
| Synonyms: | KLC2, SPOAN |
| Background: | The protein encoded by this gene is a light chain of kinesin, a molecular motor responsible for moving vesicles and organelles along microtubules. Defects in this gene are a cause of spastic paraplegia, optic atrophy, and neuropathy (SPOAN) syndrome. [provided by RefSeq, Mar 2016] |
| UniProt Protein Function: | KLC2: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. Belongs to the kinesin light chain family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motor; Microtubule-binding Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: ciliary rootlet; microtubule; kinesin complex; neuron projection; protein complex; membrane; cytosol Molecular Function:protein binding; kinesin binding; microtubule motor activity Biological Process: metabolic process; axon cargo transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; microtubule-based movement |
| NCBI Summary: | Kinesin is a molecular motor that generates ATP-dependent movement of vesicles and organelles along microtubules. Kinesin consists of 2 light chains, such as KLC2, and 2 heavy chains (see KIF5B; MIM 602809) in a 1:1 stoichiometric ratio (Rahman et al., 1998 [PubMed 9624122]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9H0B6 |
| NCBI GenInfo Identifier: | 13878553 |
| NCBI Gene ID: | 64837 |
| NCBI Accession: | Q9H0B6.1 |
| UniProt Secondary Accession: | Q9H0B6,Q9H9C8, Q9HA20, A8MXL7, B2RDY4, |
| UniProt Related Accession: | Q9H0B6 |
| Molecular Weight: | 622 |
| NCBI Full Name: | Kinesin light chain 2 |
| NCBI Synonym Full Names: | kinesin light chain 2 |
| NCBI Official Symbol: | KLC2 |
| NCBI Protein Information: | kinesin light chain 2; KLC 2 |
| UniProt Protein Name: | Kinesin light chain 2 |
| Protein Family: | Kinesin |
| UniProt Gene Name: | KLC2 |
| UniProt Entry Name: | KLC2_HUMAN |
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