Signal Transduction Antibodies 2
Anti-KLB Antibody (CAB15629)
(No reviews yet)
Write a Review
- SKU:
- CAB15629
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-KLB Antibody |
| Antibody SKU: | CAB15629 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 720-990 of human KLB (NP_783864.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, SGC-7901, rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 720-990 of human KLB (NP_783864.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ALAW RLYD RQFR PSQR GAVS LSLH ADWA EPAN PYAD SHWR AAER FLQF EIAW FAEP LFKT GDYP AAMR EYIA SKHR RGLS SSAL PRLT EAER RLLK GTVD FCAL NHFT TRFV MHEQ LAGS RYDS DRDI QFLQ DITR LSSP TRLA VIPW GVRK LLRW VRRN YGDM DIYI TASG IDDQ ALED DRLR KYYL GKYL QEVL KAYL IDKV RIKG YYAF KLAE EKSK PRFG FFTS DFKA KSSI QFYN KVIS SRGF PFEN SSSR CSQT QENT ECTV CLF |
| Gene ID: | 152831 |
| Uniprot: | Q86Z14 |
| Cellular Location: | |
| Calculated MW: | 119kDa |
| Observed MW: | 120kDa |
| Synonyms: | KLB, BKL |
| Background: |
| UniProt Protein Function: | Klotho beta: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 4p14 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:1-phosphatidylinositol-3-kinase activity; beta-glucosidase activity; fibroblast growth factor binding; fibroblast growth factor receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; Ras guanyl-nucleotide exchange factor activity; signal transducer activity Biological Process: fibroblast growth factor receptor signaling pathway; MAPKKK cascade; phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade |
| UniProt Code: | Q86Z14 |
| NCBI GenInfo Identifier: | 74750586 |
| NCBI Gene ID: | 152831 |
| NCBI Accession: | Q86Z14.1 |
| UniProt Secondary Accession: | Q86Z14,Q2M3K8, |
| UniProt Related Accession: | Q86Z14 |
| Molecular Weight: | 119,808 Da |
| NCBI Full Name: | Beta-klotho |
| NCBI Synonym Full Names: | klotho beta |
| NCBI Official Symbol: | KLB |
| NCBI Official Synonym Symbols: | BKL |
| NCBI Protein Information: | beta-klotho |
| UniProt Protein Name: | Beta-klotho |
| UniProt Synonym Protein Names: | Klotho beta-like protein |
| Protein Family: | Beta-klotho |
| UniProt Gene Name: | KLB |
| UniProt Entry Name: | KLOTB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KLB antibody (CAB15629) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
View AllClose
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
