Name: Anti-KIR2DL1 Antibody (CAB1697)
Brand: Cell Biology Antibodies 7
SKU: CAB1697
Availability: OutOfStock

Antibody Name:	Anti-KIR2DL1 Antibody
Antibody SKU:	CAB1697
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 22-270 of human KIR2DL1 (XP_003403624.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	Raji, Mouse liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 22-270 of human KIR2DL1 (XP_003403624.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	HEGV HRKP SLLA HPGR LVKS EETV ILQC WSDV RFEH FLLH REGK FKDT LHLI GEHH DGVS KANF SIGP MMQD LAGT YRCY GSVT HSPY QLSA PSDP LDIV ITGL YEKP SLSA QPGP TVLA GESV TLSC SSRS SYDM YHLS REGE AHEC RFSA GPKV NGTF QADF PLGP ATHG GTYR CFGS FRDS PYEW SNSS DPLL VSVT GNPS NSWP SPTE PSSK TERM FHHV GQAC LKLP TSSD PTVS ACQS NPRH L
Gene ID:	3802
Uniprot:	P43626
Cellular Location:	Cell membrane, Single-pass type I membrane protein
Calculated MW:	38kDa/41kDa
Observed MW:	35kDa

Synonyms:

KIR2DL1, CD158A, KIR-K64, KIR221, NKAT, NKAT-1, NKAT1, p58.1

Background:

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

UniProt Protein Function:	KIR2DL1: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2. Belongs to the immunoglobulin superfamily.
UniProt Protein Details:	Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:protein binding; receptor activity Biological Process: regulation of immune response; natural killer cell inhibitory signaling pathway; immune response
NCBI Summary:	Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
UniProt Code:	P43626
NCBI GenInfo Identifier:	1171726
NCBI Gene ID:	3802
NCBI Accession:	P43626.1
UniProt Secondary Accession:	P43626,O43470, Q32WE6, Q6IST4,
UniProt Related Accession:	P43626
Molecular Weight:	348
NCBI Full Name:	Killer cell immunoglobulin-like receptor 2DL1
NCBI Synonym Full Names:	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
NCBI Official Symbol:	KIR2DL1
NCBI Official Synonym Symbols:	NKAT; NKAT1; p58.1; CD158A; KIR221; NKAT-1; KIR-K64
NCBI Protein Information:	killer cell immunoglobulin-like receptor 2DL1; killer Ig receptor; p58 NK receptor CL-42/47.11; MHC class I NK cell receptor; killer inhibitory receptor 2-2-1; CD158 antigen-like family member A; natural killer-associated transcript 1; p58 NK cell inhibit
UniProt Protein Name:	Killer cell immunoglobulin-like receptor 2DL1
UniProt Synonym Protein Names:	CD158 antigen-like family member A; MHC class I NK cell receptor; Natural killer-associated transcript 1; NKAT-1; p58 natural killer cell receptor clones CL-42/47.11; p58 NK receptor CL-42/47.11; p58.1 MHC class-I-specific NK receptor; CD_antigen: CD158a
UniProt Gene Name:	KIR2DL1
UniProt Entry Name:	KI2L1_HUMAN

Western blot analysis of extracts of various cell lines, using KIR2DL1 antibody (CAB1697) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.

Antibodies

KIR2DL1 Antibody (PACO06904)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)