Cell Biology Antibodies 13
Anti-KIN Antibody (CAB17646)
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- SKU:
- CAB17646
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-KIN Antibody |
| Antibody SKU: | CAB17646 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-270 of human KIN (NP_036443.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | PC-3, HeLa, BxPC-3, Mouse testis, Rat thymus, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-270 of human KIN (NP_036443.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GLEG KEQE VPTF TELS REND EEKV TFNL SKGA CSSS GATS SKSS TLGP SALK TIGS SASV KRKE SSQS STQS KEKK KKKS ALDE IMEI EEE |
| Gene ID: | 22944 |
| Uniprot: | O60870 |
| Cellular Location: | |
| Calculated MW: | 43kDa/45kDa |
| Observed MW: | 45kDa |
 | Western blot - KIN Polyclonal Antibody (CAB17646) |
| Synonyms: | BTCD, KIN17, Rts2, KIN |
| Background: | The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
| UniProt Protein Function: | KIN: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C-terminal domain to RNA in vitro. Belongs to the KIN17 family. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; DNA replication Chromosomal Location of Human Ortholog: 10p14 Cellular Component: nuclear matrix; intracellular membrane-bound organelle; cytoplasm; nucleus Molecular Function:DNA binding; RNA binding; metal ion binding; double-stranded DNA binding Biological Process: viral reproduction; DNA replication; mRNA processing; DNA repair; response to DNA damage stimulus; DNA recombination |
| NCBI Summary: | The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
| UniProt Code: | O60870 |
| NCBI GenInfo Identifier: | 74762109 |
| NCBI Gene ID: | 22944 |
| NCBI Accession: | O60870.2 |
| UniProt Related Accession: | O60870 |
| Molecular Weight: | 43kDa; 45kDa |
| NCBI Full Name: | DNA/RNA-binding protein KIN17 |
| NCBI Synonym Full Names: | Kin17 DNA and RNA binding protein |
| NCBI Official Symbol: | KIN |
| NCBI Official Synonym Symbols: | BTCD; Rts2; KIN17 |
| NCBI Protein Information: | DNA/RNA-binding protein KIN17 |
| UniProt Protein Name: | DNA/RNA-binding protein KIN17 |
| UniProt Synonym Protein Names: | Binding to curved DNA; KIN, antigenic determinant of recA protein homolog |
| Protein Family: | Kinin |
| UniProt Gene Name: | KIN |
| UniProt Entry Name: | KIN17_HUMAN |
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