Cell Biology Antibodies 17
Anti-KIFAP3 Antibody (CAB5216)
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- SKU:
- CAB5216
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-KIFAP3 Antibody |
| Antibody SKU: | CAB5216 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human KIFAP3 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human KIFAP3 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 22920 |
| Uniprot: | Q92845 |
| Cellular Location: | |
| Calculated MW: | 91-100kDa |
| Observed MW: | 100KDa |
| Synonyms: | FLA3, KAP-1, KAP-3, KAP3, SMAP, Smg-GDS, dJ190I16.1 |
| Background: | The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
| UniProt Protein Function: | KIFAP3: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 1q24.2 Cellular Component: microtubule cytoskeleton; Golgi apparatus; centrosome; condensed nuclear chromosome; endoplasmic reticulum; spindle microtubule; kinesin II complex; axoneme; cytosol; photoreceptor connecting cilium Molecular Function:protein binding; kinesin binding Biological Process: negative regulation of cell proliferation; protein localization; positive regulation of calcium-dependent cell-cell adhesion; organelle organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein complex assembly; blood coagulation; signal transduction; microtubule-based movement; microtubule-based process; negative regulation of apoptosis |
| NCBI Summary: | The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
| UniProt Code: | Q92845 |
| NCBI GenInfo Identifier: | 73920216 |
| NCBI Gene ID: | 22920 |
| NCBI Accession: | Q92845.2 |
| UniProt Secondary Accession: | Q92845,Q8NHU7, Q9H416, B1AKU4, B1AKU5, B2RDL1, B7Z8A3 F5H591, |
| UniProt Related Accession: | Q92845 |
| Molecular Weight: | 792 |
| NCBI Full Name: | Kinesin-associated protein 3 |
| NCBI Synonym Full Names: | kinesin-associated protein 3 |
| NCBI Official Symbol: | KIFAP3 |
| NCBI Official Synonym Symbols: | FLA3; KAP3; SMAP; KAP-1; KAP-3; Smg-GDS; dJ190I16.1 |
| NCBI Protein Information: | kinesin-associated protein 3; smg GDS-associated protein; small G protein GDP dissociation stimulator |
| UniProt Protein Name: | Kinesin-associated protein 3 |
| UniProt Synonym Protein Names: | Smg GDS-associated protein |
| Protein Family: | Kinesin-associated protein |
| UniProt Gene Name: | KIFAP3 |
| UniProt Entry Name: | KIFA3_HUMAN |
 | Western blot - KIFAP3 Rabbit mAb (CAB5216) |
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