Cell Biology Antibodies 9
Anti-KIFAP3 Antibody (CAB4518)
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- SKU:
- CAB4518
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- KIFAP3
- Synonyms:
- FLA3
- Synonyms:
- KAP-1
- Synonyms:
- KAP-3
- Synonyms:
- KAP3
- Synonyms:
- SMAP
- Synonyms:
- Smg-GDS
- Synonyms:
- dJ190I16.1
- Research Area:
- Cell Biology
Description
| Product Name: | KIFAP3 Rabbit pAb |
| Product Code: | CAB4518 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | KIFAP3, FLA3, KAP-1, KAP-3, KAP3, SMAP, Smg-GDS, dJ190I16.1 |
| Applications: | WB, IF, IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human KIFAP3 (NP_055785.2). |
| Applications: | WB, IF, IP |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, SH-SY5Y, Mouse brain, Mouse testis, Mouse lung, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human KIFAP3 (NP_055785.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQGE DARY LKRK VKGG NIDV HPSE KALI VHYE VEAT ILGE MGDP MLGE RKEC QKII RLKS LNAN TDIT SLAR KVVE ECKL IHPS KLNE VEQL LYYL QNRR DSLS GKEK KEKS SKPK DPPP FEGM EIDE VANI NDMD EYIE LLYE DIPD KVRG SALI LQLA RNPD NLEE LLLN ETAL GALA RVLR EDWK QSVE LATN IIYI |
| Gene ID: | 22920 |
| Uniprot: | Q92845 |
| Calculated MW: | 82kDa/86kDa/91kDa |
| Observed MW: | 110kDa |
| UniProt Protein Function: | KIFAP3: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 1q24.2 Cellular Component: microtubule cytoskeleton; Golgi apparatus; centrosome; condensed nuclear chromosome; endoplasmic reticulum; spindle microtubule; kinesin II complex; axoneme; cytosol; photoreceptor connecting cilium Molecular Function:protein binding; kinesin binding Biological Process: negative regulation of cell proliferation; protein localization; positive regulation of calcium-dependent cell-cell adhesion; organelle organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein complex assembly; blood coagulation; signal transduction; microtubule-based movement; microtubule-based process; negative regulation of apoptosis |
| NCBI Summary: | The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
| UniProt Code: | Q92845 |
| NCBI GenInfo Identifier: | 73920216 |
| NCBI Gene ID: | 22920 |
| NCBI Accession: | Q92845.2 |
| UniProt Secondary Accession: | Q92845,Q8NHU7, Q9H416, B1AKU4, B1AKU5, B2RDL1, B7Z8A3 F5H591, |
| UniProt Related Accession: | Q92845 |
| Molecular Weight: | 792 |
| NCBI Full Name: | Kinesin-associated protein 3 |
| NCBI Synonym Full Names: | kinesin-associated protein 3 |
| NCBI Official Symbol: | KIFAP3 |
| NCBI Official Synonym Symbols: | FLA3; KAP3; SMAP; KAP-1; KAP-3; Smg-GDS; dJ190I16.1 |
| NCBI Protein Information: | kinesin-associated protein 3; smg GDS-associated protein; small G protein GDP dissociation stimulator |
| UniProt Protein Name: | Kinesin-associated protein 3 |
| UniProt Synonym Protein Names: | Smg GDS-associated protein |
| Protein Family: | Kinesin-associated protein |
| UniProt Gene Name: | KIFAP3 |
| UniProt Entry Name: | KIFA3_HUMAN |
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