Cell Biology Antibodies 6

Anti-KIF3B Antibody (CAB15754)

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SKU:
CAB15754
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-KIF3B Antibody
Antibody SKU:CAB15754
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 663-747 of human KIF3B (NP_004789.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 663-747 of human KIF3B (NP_004789.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LELD MPSR TTRD YEGP AIAP KVQA ALDA ALQD EDEI QVDA SSFE STAN KKSK ARPK SGRK SGSS SSSS GTPA SQLY PQSR GLVP K
Gene ID:9371
Uniprot:O15066
Cellular Location:Cytoplasm, cytoskeleton
Calculated MW:43kDa/85kDa
Observed MW:100kDa
Synonyms:KIF3B, FLA8, HH0048, KLP-11
Background:The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily.
UniProt Protein Function:KIF3B: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Belongs to the kinesin-like protein family. Kinesin II subfamily.
UniProt Protein Details:

Protein type:Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 20q11.21

Cellular Component: cytosol; kinesin II complex; membrane; microtubule cytoskeleton; plus-end kinesin complex

Molecular Function:microtubule motor activity; plus-end-directed microtubule motor activity; protein binding; Rho GTPase binding

Biological Process: anterograde axon cargo transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; determination of left/right symmetry; microtubule-based movement; mitotic centrosome separation; mitotic spindle organization and biogenesis; retrograde vesicle-mediated transport, Golgi to ER

NCBI Summary:The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]
UniProt Code:O15066
NCBI GenInfo Identifier:3913958
NCBI Gene ID:9371
NCBI Accession:O15066.1
UniProt Secondary Accession:O15066,B2RMP4, B4DSR5, E1P5M5,
UniProt Related Accession:O15066
Molecular Weight:43,269 Da
NCBI Full Name:Kinesin-like protein KIF3B
NCBI Synonym Full Names:kinesin family member 3B
NCBI Official Symbol:KIF3B  
NCBI Official Synonym Symbols:FLA8; HH0048; KLP-11  
NCBI Protein Information:kinesin-like protein KIF3B
UniProt Protein Name:Kinesin-like protein KIF3B
UniProt Synonym Protein Names:HH0048; Microtubule plus end-directed kinesin motor 3B
Protein Family:Kinesin-like protein
UniProt Gene Name:KIF3B  
UniProt Entry Name:KIF3B_HUMAN
Anti-KIF3B Antibody (CAB15754)Western blot analysis of extracts of various cell lines, using KIF3B antibody (CAB15754) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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