Cell Death Antibodies 2
Anti-KIF1B Antibody (CAB6638)
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- SKU:
- CAB6638
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-KIF1B Antibody |
| Antibody SKU: | CAB6638 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1501-1770 of human KIF1B (NP_055889.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SKOV3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1501-1770 of human KIF1B (NP_055889.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SQIS TTTF ESAI TPSE SSGY DSGD IESL VDRE KELA TKCL QLLT HTFN REFS QVHG SVSD CKLS DISP IGRD PSES SFSS ATLT PSST CPSL VDSR SNSL DQKT PEAN SRAS SPCP EFEQ FQIV PAVE TPYL ARAG KNEF LNLV PDIE EIRP SSVV SKKG YLHF KEPL YSNW AKHF VVVR RPYV FIYN SDKD PVER GIIN LSTA QVEY SEDQ QAMV KTPN TFAV CTKH RGVL LQAL NDKD MNDW LYAF NPLL AGTI RSKL SRRC PSQS KY |
| Gene ID: | 23095 |
| Uniprot: | O60333 |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, Mitochondrion, cytoskeleton |
| Calculated MW: | 130kDa/199kDa/204kDa/205kDa |
| Observed MW: | 204kDa |
| Synonyms: | KIF1B, CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1 |
| Background: | This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. |
| UniProt Protein Function: | KIF1B: a member of the kinesin motor protein family. Motor for anterograde transport of mitochondria. May play a role in synaptic vesicle transport. Has a microtubule plus end-directed motility. Aberrant expression seen in neuroblastoma. Mutated in Charcot-Marie-Tooth disease. |
| UniProt Protein Details: | Protein type:Microtubule-binding; Motor Chromosomal Location of Human Ortholog: 1p36.2 Cellular Component: microtubule; kinesin complex; neuron projection; microtubule associated complex; cytoplasmic vesicle membrane; mitochondrion; cytoplasmic vesicle Molecular Function:protein binding; kinesin binding; plus-end-directed microtubule motor activity; microtubule binding; ATPase activity; microtubule motor activity; ATP binding Biological Process: vesicle-mediated transport; apoptosis; metabolic process; neuromuscular synaptic transmission; nerve-nerve synaptic transmission; cytoskeleton-dependent intracellular transport; anterograde axon cargo transport; microtubule-based movement; mitochondrion transport along microtubule Disease: Charcot-marie-tooth Disease, Axonal, Type 2a1; Neuroblastoma, Susceptibility To; Pheochromocytoma |
| NCBI Summary: | This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60333 |
| NCBI GenInfo Identifier: | 116242605 |
| NCBI Gene ID: | 23095 |
| NCBI Accession: | O60333.5 |
| UniProt Secondary Accession: | O60333,Q4VXC3, Q4VXC4, Q4VXC5, Q4VXC6, Q96Q94, Q9BV80 Q9P280, A6NFS8, A6NKQ4, |
| UniProt Related Accession: | O60333 |
| Molecular Weight: | 1816 |
| NCBI Full Name: | Kinesin-like protein KIF1B |
| NCBI Synonym Full Names: | kinesin family member 1B |
| NCBI Official Symbol: | KIF1B |
| NCBI Official Synonym Symbols: | KLP; CMT2; CMT2A; CMT2A1; HMSNII; NBLST1 |
| NCBI Protein Information: | kinesin-like protein KIF1B; kinesin superfamily protein KIF1B |
| UniProt Protein Name: | Kinesin-like protein KIF1B |
| Protein Family: | Kinesin-like protein |
| UniProt Gene Name: | KIF1B |
| UniProt Entry Name: | KIF1B_HUMAN |
 | Western blot analysis of extracts of SKOV3 cells, using KIF1B antibody (CAB6638) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver damage using KIF1B Antibody (CAB6638) at dilution of 1:100 (40x lens). |
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