Cell Biology Antibodies 5
Anti-KIF18A Antibody (CAB14939)
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- SKU:
- CAB14939
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-KIF18A Antibody |
| Antibody SKU: | CAB14939 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 599-898 of human KIF18A (NP_112494.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 599-898 of human KIF18A (NP_112494.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SDFK EIEH LVER KKVV VWAD QTAE QPKQ NDLP GISV LMTF PQLG PVQP IPCC SSSG GTNL VKIP TEKR TRRK LMPS PLKG QHTL KSPP SQSV QLND SLSK ELQP IVYT PEDC RKAF QNPS TVTL MKPS SFTT SFQA ISSN INSD NCLK MLCE VAIP HNRR KECG QEDL DSTF TICE DIKS SKCK LPEQ ESLP NDNK DILQ RLDP SSFS TKHS MPVP SMVP SYMA MTTA AKRK RKLT SSTS NSSL TADV NSGF AKRV RQDN SSEK HLQE NKPT MEHK RNIC KINP SMVR KFGR NISK GNLR |
| Gene ID: | 81930 |
| Uniprot: | Q8NI77 |
| Cellular Location: | Cell projection, Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, ruffle |
| Calculated MW: | 102kDa |
| Observed MW: | Refer to figures |
| Synonyms: | KIF18A, MS-KIF18A, PPP1R99 |
| Background: |
| UniProt Protein Function: | KIF18A: Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. Belongs to the kinesin-like protein family. |
| UniProt Protein Details: | Protein type:Motor; Microtubule-binding Chromosomal Location of Human Ortholog: 11p14.1 Cellular Component: caveola; cytoplasm; cytosol; kinesin complex; kinetochore microtubule; microtubule cytoskeleton; nucleus; ruffle Molecular Function:actin binding; microtubule binding; microtubule plus-end binding; plus-end-directed microtubule motor activity; protein binding; ubiquitin binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule depolymerization; microtubule-based movement; mitotic metaphase plate congression; retrograde vesicle-mediated transport, Golgi to ER; sister chromatid cohesion |
| NCBI Summary: | KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008] |
| UniProt Code: | Q8NI77 |
| NCBI GenInfo Identifier: | 66774137 |
| NCBI Gene ID: | 81930 |
| NCBI Accession: | Q8NI77.2 |
| UniProt Secondary Accession: | Q8NI77,Q4VPE3, Q86VS5, Q9H0F3, |
| UniProt Related Accession: | Q8NI77 |
| Molecular Weight: | 102,281 Da |
| NCBI Full Name: | Kinesin-like protein KIF18A |
| NCBI Synonym Full Names: | kinesin family member 18A |
| NCBI Official Symbol: | KIF18A |
| NCBI Official Synonym Symbols: | PPP1R99; MS-KIF18A |
| NCBI Protein Information: | kinesin-like protein KIF18A |
| UniProt Protein Name: | Kinesin-like protein KIF18A |
| UniProt Synonym Protein Names: | Marrow stromal KIF18A; MS-KIF18A |
| Protein Family: | Kinesin-like protein |
| UniProt Gene Name: | KIF18A |
| UniProt Entry Name: | KI18A_HUMAN |
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