Cell Biology Antibodies 5

Anti-KIF18A Antibody (CAB14939)

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SKU:
CAB14939
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-KIF18A Antibody
Antibody SKU:CAB14939
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 599-898 of human KIF18A (NP_112494.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 599-898 of human KIF18A (NP_112494.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SDFK EIEH LVER KKVV VWAD QTAE QPKQ NDLP GISV LMTF PQLG PVQP IPCC SSSG GTNL VKIP TEKR TRRK LMPS PLKG QHTL KSPP SQSV QLND SLSK ELQP IVYT PEDC RKAF QNPS TVTL MKPS SFTT SFQA ISSN INSD NCLK MLCE VAIP HNRR KECG QEDL DSTF TICE DIKS SKCK LPEQ ESLP NDNK DILQ RLDP SSFS TKHS MPVP SMVP SYMA MTTA AKRK RKLT SSTS NSSL TADV NSGF AKRV RQDN SSEK HLQE NKPT MEHK RNIC KINP SMVR KFGR NISK GNLR
Gene ID:81930
Uniprot:Q8NI77
Cellular Location:Cell projection, Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, ruffle
Calculated MW:102kDa
Observed MW:Refer to figures
Synonyms:KIF18A, MS-KIF18A, PPP1R99
Background:
UniProt Protein Function:KIF18A: Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. Belongs to the kinesin-like protein family.
UniProt Protein Details:

Protein type:Motor; Microtubule-binding

Chromosomal Location of Human Ortholog: 11p14.1

Cellular Component: caveola; cytoplasm; cytosol; kinesin complex; kinetochore microtubule; microtubule cytoskeleton; nucleus; ruffle

Molecular Function:actin binding; microtubule binding; microtubule plus-end binding; plus-end-directed microtubule motor activity; protein binding; ubiquitin binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule depolymerization; microtubule-based movement; mitotic metaphase plate congression; retrograde vesicle-mediated transport, Golgi to ER; sister chromatid cohesion

NCBI Summary:KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]
UniProt Code:Q8NI77
NCBI GenInfo Identifier:66774137
NCBI Gene ID:81930
NCBI Accession:Q8NI77.2
UniProt Secondary Accession:Q8NI77,Q4VPE3, Q86VS5, Q9H0F3,
UniProt Related Accession:Q8NI77
Molecular Weight:102,281 Da
NCBI Full Name:Kinesin-like protein KIF18A
NCBI Synonym Full Names:kinesin family member 18A
NCBI Official Symbol:KIF18A  
NCBI Official Synonym Symbols:PPP1R99; MS-KIF18A  
NCBI Protein Information:kinesin-like protein KIF18A
UniProt Protein Name:Kinesin-like protein KIF18A
UniProt Synonym Protein Names:Marrow stromal KIF18A; MS-KIF18A
Protein Family:Kinesin-like protein
UniProt Gene Name:KIF18A  
UniProt Entry Name:KI18A_HUMAN
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