Neuroscience

Anti-KIAA0319 Antibody (CAB15369)

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SKU:
CAB15369
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Neuroscience

Description

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Antibody Name:Anti-KIAA0319 Antibody
Antibody SKU:CAB15369
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-300 of human KIAA0319 (NP_055624.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-87MG, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-300 of human KIAA0319 (NP_055624.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ARKQ CSEG RTYS NAVI SPNL ETTR IMRV SHTF PVVD CTAA CCDL SSCD LAWW FEGR CYLV SCPH KENC EPKK MGPI RSYL TFVL RPVQ RPAQ LLDY GDMM LNRG SPSG IWGD SPED IRKD LTFL GKDW GLEE MSEY SDDY RELE KDLL QPSG KQEP RGSA EYTD WGLL PGSE GAFN SSVG DSPA VPAE TQQD PELH YLNE SAST PAPK LPER SVLL PLPT TPSS GEVL EKEK ASQL QEQS SNSS GKEV LMPS HSLP PASL ELSS VTVE KSPV LTVT PGST
Gene ID:9856
Uniprot:Q5VV43
Cellular Location:Cell membrane, Early endosome membrane, Single-pass type I membrane protein
Calculated MW:110kDa/113kDa/117kDa
Observed MW:118kDa
Synonyms:KIAA0319, DYLX2, DYX2, NMIG
Background:This gene encodes a transmembrane protein that contains a large extracellular domain with multiple polycystic kidney disease (PKD) domains. The encoded protein may play a role in the development of the cerebral cortex by regulating neuronal migration and cell adhesion. Single nucleotide polymorphisms in this gene are associated with dyslexia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:KIAA0319: Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. Defects in KIAA0319 may be a cause of susceptibility to dyslexia type 2 (DYX2); also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability. A lower expression is associated with the risk haplotype. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: early endosome membrane; early endosome; plasma membrane; integral to membrane

Molecular Function:protein binding

Biological Process: neuron migration

Disease: Dyslexia, Susceptibility To, 2

NCBI Summary:This gene encodes a transmembrane protein that contains a large extracellular domain with multiple polycystic kidney disease (PKD) domains. The encoded protein may play a role in the development of the cerebral cortex by regulating neuronal migration and cell adhesion. Single nucleotide polymorphisms in this gene are associated with dyslexia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
UniProt Code:Q5VV43
NCBI GenInfo Identifier:270265853
NCBI Gene ID:9856
NCBI Accession:NP_001161846.1
UniProt Secondary Accession:Q5VV43,Q9UJC8, Q9Y4G7, A7MD37, B2RTU7, B4DHA7, B4DK75 B7ZML3, F5H123,
UniProt Related Accession:Q5VV43
Molecular Weight:117,763 Da
NCBI Full Name:dyslexia-associated protein KIAA0319 isoform b
NCBI Synonym Full Names:KIAA0319
NCBI Official Symbol:KIAA0319  
NCBI Official Synonym Symbols:DYX2; NMIG; DYLX2  
NCBI Protein Information:dyslexia-associated protein KIAA0319; neuronal migration; dyslexia susceptibility 2
UniProt Protein Name:Dyslexia-associated protein KIAA0319
Protein Family:Dyslexia-associated protein
UniProt Gene Name:KIAA0319  
UniProt Entry Name:K0319_HUMAN
Anti-KIAA0319 Antibody (CAB15369)Western blot analysis of extracts of various cell lines, using KIAA0319 antibody (CAB15369) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5s.
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