Immunology Antibodies 2

Anti-KHDRBS3 Antibody (CAB6637)

(No reviews yet) Write a Review
SKU:
CAB6637
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-KHDRBS3 Antibody
Antibody SKU:CAB6637
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 177-346 of human KHDRBS3 (NP_006549.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:SW480, BT-474, HepG2, Jurkat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 177-346 of human KHDRBS3 (NP_006549.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GSEN ADVP VVRG KPTL RTRG VPAP AITR GRGG VTAR PVGV VVPR GTPT PRGV LSTR GPVS RGRG LLTP RARG VPPT GYRP PPPP PTQE TYGE YDYD DGYG TAYD EQSY DSYD NSYS TPAQ SGAD YYDY GHGL SEET YDSY GQEE WTNS RHKA PSAR TAKG VYRD QPYG RY
Gene ID:10656
Uniprot:O75525
Cellular Location:Nucleus
Calculated MW:30kDa/38kDa
Observed MW:39kDa
Synonyms:KHDRBS3, Etle, SALP, SLM-2, SLM2, T-STAR, TSTAR, etoile
Background:
UniProt Protein Function:KHDRBS3: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA- binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Belongs to the KHDRBS family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 8q24.2

Cellular Component: nucleoplasm; nucleus

Molecular Function:protein binding; RNA binding; SH3 domain binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; spermatogenesis

UniProt Code:O75525
NCBI GenInfo Identifier:74735514
NCBI Gene ID:10656
NCBI Accession:O75525.1
UniProt Secondary Accession:O75525,Q9R226,
UniProt Related Accession:O75525
Molecular Weight:346
NCBI Full Name:KH domain-containing, RNA-binding, signal transduction-associated protein 3
NCBI Synonym Full Names:KH domain containing, RNA binding, signal transduction associated 3
NCBI Official Symbol:KHDRBS3  
NCBI Official Synonym Symbols:Etle; SALP; SLM2; SLM-2; TSTAR; T-STAR; etoile  
NCBI Protein Information:KH domain-containing, RNA-binding, signal transduction-associated protein 3; RNA-binding protein T-Star; sam68-like mammalian protein 2; Sam68-like phosphotyrosine protein, T-STAR
UniProt Protein Name:KH domain-containing, RNA-binding, signal transduction-associated protein 3
UniProt Synonym Protein Names:RNA-binding protein T-Star; Sam68-like mammalian protein 2; SLM-2; Sam68-like phosphotyrosine protein
Protein Family:Phosphatidylinositol 4,5-bisphosphate-binding protein
UniProt Gene Name:KHDRBS3  
UniProt Entry Name:KHDR3_HUMAN
Anti-KHDRBS3 Antibody (CAB6637)Western blot analysis of extracts of various cell lines, using KHDRBS3 antibody (CAB6637) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
Anti-KHDRBS3 Antibody (CAB6637)Immunofluorescence analysis of MCF7 cells using KHDRBS3 antibody (CAB6637).
View AllClose

0 Reviews

View AllClose

Related Products