Epigenetics & Nuclear Signaling Antibodies 2
Anti-KHDRBS2 Antibody (CAB6102)
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- SKU:
- CAB6102
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-KHDRBS2 Antibody |
| Antibody SKU: | CAB6102 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human KHDRBS2 (NP_689901.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, 293T, Jurkat, K-562 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human KHDRBS2 (NP_689901.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TAPS RGRG GAIP PPPP PGRG VLTP RGST VTRG ALPV PPVA RGVP TPRA RGAP TVPG YRAP PPPA HEAY EEYG YDDG YGGE YDDQ TYET YDNS YATQ TQSV PEYY DYGH GVSE DAYD SYAP EEWA TTRS SLKA PPQR SARG GYRE HPYG RY |
| Gene ID: | 202559 |
| Uniprot: | Q5VWX1 |
| Cellular Location: | Nucleus |
| Calculated MW: | 38kDa |
| Observed MW: | 39kDa |
| Synonyms: | KHDRBS2, SLM-1, SLM1 |
| Background: |
| UniProt Protein Function: | KHDRBS2: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. Belongs to the KHDRBS family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6q11.1 Cellular Component: nucleoplasm Molecular Function:protein binding |
| UniProt Code: | Q5VWX1 |
| NCBI GenInfo Identifier: | 74762274 |
| NCBI Gene ID: | 202559 |
| NCBI Accession: | Q5VWX1.1 |
| UniProt Secondary Accession: | Q5VWX1,Q8N4I4, Q8TCZ4, A8K7M8, |
| UniProt Related Accession: | Q5VWX1 |
| Molecular Weight: | 38,927 Da |
| NCBI Full Name: | KH domain-containing, RNA-binding, signal transduction-associated protein 2 |
| NCBI Synonym Full Names: | KH RNA binding domain containing, signal transduction associated 2 |
| NCBI Official Symbol: | KHDRBS2 |
| NCBI Official Synonym Symbols: | SLM1; SLM-1 |
| NCBI Protein Information: | KH domain-containing, RNA-binding, signal transduction-associated protein 2 |
| UniProt Protein Name: | KH domain-containing, RNA-binding, signal transduction-associated protein 2 |
| UniProt Synonym Protein Names: | Sam68-like mammalian protein 1; SLM-1; hSLM-1 |
| Protein Family: | KH domain-containing, RNA-binding, signal transduction-associated protein |
| UniProt Gene Name: | KHDRBS2 |
| UniProt Entry Name: | KHDR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KHDRBS2 antibody (CAB6102) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using KHDRBS2 antibody (CAB6102) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophagus using KHDRBS2 antibody (CAB6102) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using KHDRBS2 antibody (CAB6102) at dilution of 1:100 (40x lens). |
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