Epigenetics & Nuclear Signaling Antibodies 5
Anti-KDM4B / JMJD2B Antibody (CAB6670)
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- SKU:
- CAB6670
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-KDM4B / JMJD2B Antibody |
| Antibody SKU: | CAB6670 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human KDM4B / JMJD2B |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HCT116, Mouse brain |
| Immunogen: | A synthesized peptide derived from human KDM4B / JMJD2B |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 23030 |
| Uniprot: | O94953 |
| Cellular Location: | |
| Calculated MW: | 150kDa |
| Observed MW: | 150KDa |
| Synonyms: | JMJD2B, TDRD14B |
| Background: |
| UniProt Protein Function: | JMJD2B: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Belongs to the JHDM3 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.14.11.-; Oxidoreductase; Demethylase Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:histone demethylase activity |
| UniProt Code: | O94953 |
| NCBI GenInfo Identifier: | 134047803 |
| NCBI Gene ID: | 23030 |
| NCBI Accession: | O94953.4 |
| UniProt Secondary Accession: | O94953,O75274, Q6P3R5, Q9P1V1, Q9UF40, B9EGN8, D6W631 |
| UniProt Related Accession: | O94953 |
| Molecular Weight: | 50,582 Da |
| NCBI Full Name: | Lysine-specific demethylase 4B |
| NCBI Synonym Full Names: | lysine demethylase 4B |
| NCBI Official Symbol: | KDM4B |
| NCBI Official Synonym Symbols: | JMJD2B; TDRD14B |
| NCBI Protein Information: | lysine-specific demethylase 4B |
| UniProt Protein Name: | Lysine-specific demethylase 4B |
| UniProt Synonym Protein Names: | JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B |
| Protein Family: | Lysine-specific demethylase |
| UniProt Gene Name: | KDM4B |
| UniProt Entry Name: | KDM4B_HUMAN |
 | Western blot - KDM4B / JMJD2B Rabbit mAb (CAB6670) |
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