Immunology Antibodies 3
Anti-KDM4A Antibody (CAB9267)
(No reviews yet)
Write a Review
- SKU:
- CAB9267
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-KDM4A Antibody |
| Antibody SKU: | CAB9267 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human KDM4A |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, NIH/3T3, SH-SY5Y |
| Immunogen: | A synthesized peptide derived from human KDM4A |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9682 |
| Uniprot: | O75164 |
| Cellular Location: | |
| Calculated MW: | 150kDa |
| Observed MW: | 150KDa |
| Synonyms: | JHDM3A, JMJD2, JMJD2A, TDRD14A |
| Background: | This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009] |
| UniProt Protein Function: | JMJD2A: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1. Interacts with HTLV-1 Tax protein. Ubiquitous. Belongs to the JHDM3 histone demethylase family. |
| UniProt Protein Details: | Protein type:EC 1.14.11.-; Demethylase; Oxidoreductase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus Molecular Function:histone demethylase activity; histone demethylase activity (H3-K36 specific); methylated histone residue binding; protein binding; ubiquitin protein ligase binding Biological Process: histone demethylation; negative regulation of autophagy; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009] |
| UniProt Code: | O75164 |
| NCBI GenInfo Identifier: | 308153457 |
| NCBI Gene ID: | 9682 |
| NCBI Accession: | O75164.2 |
| UniProt Secondary Accession: | O75164,Q5VVB1, |
| UniProt Related Accession: | O75164 |
| Molecular Weight: | 54,697 Da |
| NCBI Full Name: | Lysine-specific demethylase 4A |
| NCBI Synonym Full Names: | lysine demethylase 4A |
| NCBI Official Symbol: | KDM4A |
| NCBI Official Synonym Symbols: | JMJD2; JHDM3A; JMJD2A; TDRD14A |
| NCBI Protein Information: | lysine-specific demethylase 4A |
| UniProt Protein Name: | Lysine-specific demethylase 4A |
| UniProt Synonym Protein Names: | JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A |
| Protein Family: | Lysine-specific demethylase |
| UniProt Gene Name: | KDM4A |
| UniProt Entry Name: | KDM4A_HUMAN |
 | Western blot - KDM4A Rabbit mAb (CAB9267) |
View AllClose
Related Products
KDM4A Monoclonal Antibody
OverviewProduct Name:KDM4A Monoclonal AntibodyProduct Code:CAB22060Reactivity:Human, Mouse, RatApplications:Western blotting, Imm
Anti-RANBP3 Antibody (CAB0092)
OverviewProduct Name:RANBP3 Rabbit mAbProduct Code:CAB0092Size:20uL, 50uL, 100uLSynonyms:RANBP3, ran-binding protein 3
Anti-QK1 Antibody (CAB0193)
OverviewProduct Name:QK1 Rabbit mAbProduct Code:CAB0193Size:20uL, 50uL, 100uLSynonyms:QKI, Hqk, QK, QK1, QK3, hqkI, protein quaking