Name: Anti-KDM4A Antibody (CAB9267)
Brand: Immunology Antibodies 3
SKU: CAB9267
Availability: OutOfStock

Antibody Name:	Anti-KDM4A Antibody
Antibody SKU:	CAB9267
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human KDM4A

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	HeLa, NIH/3T3, SH-SY5Y

Immunogen:	A synthesized peptide derived from human KDM4A
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	9682
Uniprot:	O75164
Cellular Location:
Calculated MW:	150kDa
Observed MW:	150KDa

Synonyms:

JHDM3A, JMJD2, JMJD2A, TDRD14A

Background:

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]

UniProt Protein Function:	JMJD2A: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1. Interacts with HTLV-1 Tax protein. Ubiquitous. Belongs to the JHDM3 histone demethylase family.
UniProt Protein Details:	Protein type:EC 1.14.11.-; Demethylase; Oxidoreductase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus Molecular Function:histone demethylase activity; histone demethylase activity (H3-K36 specific); methylated histone residue binding; protein binding; ubiquitin protein ligase binding Biological Process: histone demethylation; negative regulation of autophagy; negative regulation of transcription, DNA-dependent
NCBI Summary:	This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]
UniProt Code:	O75164
NCBI GenInfo Identifier:	308153457
NCBI Gene ID:	9682
NCBI Accession:	O75164.2
UniProt Secondary Accession:	O75164,Q5VVB1,
UniProt Related Accession:	O75164
Molecular Weight:	54,697 Da
NCBI Full Name:	Lysine-specific demethylase 4A
NCBI Synonym Full Names:	lysine demethylase 4A
NCBI Official Symbol:	KDM4A
NCBI Official Synonym Symbols:	JMJD2; JHDM3A; JMJD2A; TDRD14A
NCBI Protein Information:	lysine-specific demethylase 4A
UniProt Protein Name:	Lysine-specific demethylase 4A
UniProt Synonym Protein Names:	JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A
Protein Family:	Lysine-specific demethylase
UniProt Gene Name:	KDM4A
UniProt Entry Name:	KDM4A_HUMAN