Immunology Antibodies 2
Anti-KDM4A Antibody (CAB7953)
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- SKU:
- CAB7953
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Applications:
- IP
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | KDM4A Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB7953 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IP |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 585-815 of human KDM4A (NP_055478.2). |
| Application: | WB IHC IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | BT-474, THP-1, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 585-815 of human KDM4A (NP_055478.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FSLE ENKK SKGR RQPL SKLP RHHP LVLQ ECVS DDET SEQL TPEE EAEE TEAW AKPL SQLW QNRP PNFE AEKE FNET MAQQ APHC AVCM IFQT YHQV EFGG FNQN CGNA SDLA PQKQ RTKP LIPE MCFT STGC STDI NLST PYLE EDGT SILV SCKK CSVR VHAS CYGV PPAK ASED WMCS RCSA NALE EDCC LCSL RGGA LQRA NDDR WVHV SCAV AILE ARFV NIAE RSP |
| Gene ID: | 9682 |
| Uniprot: | O75164 |
| Cellular Location: | Nucleus |
| Calculated MW: | 54kDa/120kDa |
| Observed MW: | 150kDa |
| Synonyms: | KDM4A, JHDM3A, JMJD2, JMJD2A, TDRD14A |
| Background: | This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. |
| UniProt Protein Function: | JMJD2A: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1. Interacts with HTLV-1 Tax protein. Ubiquitous. Belongs to the JHDM3 histone demethylase family. |
| UniProt Protein Details: | Protein type:EC 1.14.11.-; Demethylase; Oxidoreductase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus Molecular Function:histone demethylase activity; histone demethylase activity (H3-K36 specific); methylated histone residue binding; protein binding; ubiquitin protein ligase binding Biological Process: histone demethylation; negative regulation of autophagy; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009] |
| UniProt Code: | O75164 |
| NCBI GenInfo Identifier: | 308153457 |
| NCBI Gene ID: | 9682 |
| NCBI Accession: | O75164.2 |
| UniProt Secondary Accession: | O75164,Q5VVB1, |
| UniProt Related Accession: | O75164 |
| Molecular Weight: | 54,697 Da |
| NCBI Full Name: | Lysine-specific demethylase 4A |
| NCBI Synonym Full Names: | lysine demethylase 4A |
| NCBI Official Symbol: | KDM4A |
| NCBI Official Synonym Symbols: | JMJD2; JHDM3A; JMJD2A; TDRD14A |
| NCBI Protein Information: | lysine-specific demethylase 4A |
| UniProt Protein Name: | Lysine-specific demethylase 4A |
| UniProt Synonym Protein Names: | JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A |
| Protein Family: | Lysine-specific demethylase |
| UniProt Gene Name: | KDM4A |
| UniProt Entry Name: | KDM4A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KDM4A antibody (CAB7953) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse lung using KDM4A antibody (CAB7953) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse liver using KDM4A antibody (CAB7953) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using KDM4A antibody (CAB7953) at dilution of 1:100 (40x lens). |
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