Immunology Antibodies 1
Anti-KDM4A Antibody (CAB12551)
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- SKU:
- CAB12551
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-KDM4A Antibody |
| Antibody SKU: | CAB12551 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 825-1064 of human KDM4A (NP_055478.2). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 825-1064 of human KDM4A (NP_055478.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RFKL KCIF CKKR RKRT AGCC VQCS HGRC PTAF HVSC AQAA GVMM QPDD WPFV VFIT CFRH KIPN LERA KGAL QSIT AGQK VISK HKNG RFYQ CEVV RLTT ETFY EVNF DDGS FSDN LYPE DIVS QDCL QFGP PAEG EVVQ VRWT DGQV YGAK FVAS HPIQ MYQV EFED GSQL VVKR DDVY TLDE ELPK RVKS RLSV ASDM RFNE IFTE KEVK QEKK RQRV INSR YRED YIEP ALYR AIME |
| Gene ID: | 9682 |
| Uniprot: | O75164 |
| Cellular Location: | Nucleus |
| Calculated MW: | 54kDa/120kDa |
| Observed MW: | Refer to figures |
| Synonyms: | KDM4A, JHDM3A, JMJD2, JMJD2A, TDRD14A |
| Background: | This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. |
| UniProt Protein Function: | JMJD2A: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1. Interacts with HTLV-1 Tax protein. Ubiquitous. Belongs to the JHDM3 histone demethylase family. |
| UniProt Protein Details: | Protein type:EC 1.14.11.-; Demethylase; Oxidoreductase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus Molecular Function:histone demethylase activity; histone demethylase activity (H3-K36 specific); methylated histone residue binding; protein binding; ubiquitin protein ligase binding Biological Process: histone demethylation; negative regulation of autophagy; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009] |
| UniProt Code: | O75164 |
| NCBI GenInfo Identifier: | 308153457 |
| NCBI Gene ID: | 9682 |
| NCBI Accession: | O75164.2 |
| UniProt Secondary Accession: | O75164,Q5VVB1, |
| UniProt Related Accession: | O75164 |
| Molecular Weight: | 54,697 Da |
| NCBI Full Name: | Lysine-specific demethylase 4A |
| NCBI Synonym Full Names: | lysine demethylase 4A |
| NCBI Official Symbol: | KDM4A |
| NCBI Official Synonym Symbols: | JMJD2; JHDM3A; JMJD2A; TDRD14A |
| NCBI Protein Information: | lysine-specific demethylase 4A |
| UniProt Protein Name: | Lysine-specific demethylase 4A |
| UniProt Synonym Protein Names: | JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A |
| Protein Family: | Lysine-specific demethylase |
| UniProt Gene Name: | KDM4A |
| UniProt Entry Name: | KDM4A_HUMAN |
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